DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RanGAP and rangap1

DIOPT Version :9

Sequence 1:	NP_001260578.1	Gene:	RanGAP / 35223	FlyBaseID:	FBgn0003346	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_012816044.1	Gene:	rangap1 / 100144714	XenbaseID:	XB-GENE-489955	Length:	589	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	199/565 - (35%)
Similarity:	316/565 - (55%)	Gaps:	41/565 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTFNFASMAAQLGQ---EQG--ISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVE 60
            |::.:.|.:...|.:   |.|  :||:.|.|..|||.|.::|:..:.....:|.|.|:|||:|:|
Frog     8 MASEDIAQLTDSLAKTKVEGGGELSFKGKSLKLNTAQDAEEVIREIEDFEGLHALRLEGNTVGLE 72

  Fly    61 AAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGM 125
            |||||.:.|::.|:.::..|.:||||||.||||.:|..||.|||.|||:||.|||||||.||:|:
Frog    73 AAKAIAKVLEKKPDLKRCHWSDMFTGRLRSEIPPSLISLGDALITAGAQLTELDLSDNAFGPDGV 137

  Fly   126 RGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLED 190
            ||.|.||:||.|::||||.|.|||:|..||.:|:.||.:.:..::..|.||.|:|||..|||||:
Frog   138 RGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECYKKSSSHGKPLALKVFIAGRNRLEN 202

  Fly   191 AGATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEA 255
            .|||.:|.||:.:.|.||:.:.||.|...|:.|||||||.|..|:|:|:||||...:|...:|||
Frog   203 DGATALAEAFRLIGTLEEVHMPQNGINHAGITALAESFKANSLLKVINLNDNTFTEKGGIAMAEA 267

  Fly   256 LPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLR 320
            |..|..:..::|||||:::.||.....||:.|..:|:.::|.|.||..|..:||..::.::.:|:
Frog   268 LKTLRQVEVINFGDCLVRSKGAQAIATALKEGLHKLKELNLSFCEIKRDAAVVLAESVEDRSELQ 332

  Fly   321 ILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHAN 385
            .|:|:||..||.|.|::...:..:..|..|......|.::.|||.:.|..|.|.:::::
Frog   333 KLDLNGNCLGEGGCEQVQEILEGISMANILGSLSDDEGDEDEDEDEVDDDDDDDDDDDD------ 391

  Fly   386 DTTEEADEDSEGDEDDEEDEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETFAVANKTIS 450
               |:.:||.|.:|::|:.:.:|..:...:.:::|:|.|...||..|.:..::..
Frog   392 ---EDDEEDVEEEEEEEDVDDNENRTKPNKISSHVSTPAAPPKLPVDASTFLSFP---------- 443

  Fly   451 QKCTPEKFCL---SQKPCSQEDFDSLDMDNKLEALQSIVNQFTGDNHLLLLVFTT----LKCAHL 508
               :|||...   .:.....:..|..|.:..::....:.:.:..|:.:...|..|    :|.|..
Frog   444 ---SPEKLVRMGPKRSTMIMQQIDVADTEKVVQTFIQVSSVYRDDSEVKAAVEETIDGLMKKAFE 505

  Fly   509 SQSSKAAL---DLAVSLYQATFDYAIKTKQETR----VLNYVLMQ 546
            |:..:..|   .|.|.:.....:..|||.|...    .||:::.|
Frog   506 SRGFQENLFITSLLVHMGLLKSEDKIKTVQHLNGPLLTLNHMVQQ 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanGAP	NP_001260578.1	leucine-rich repeat	45..77	CDD:275380	15/31 (48%)
		LRR_RI	50..337	CDD:238064	141/286 (49%)
		leucine-rich repeat	78..109	CDD:275380	19/30 (63%)
		leucine-rich repeat	110..139	CDD:275380	20/28 (71%)
		leucine-rich repeat	140..167	CDD:275380	14/26 (54%)
		leucine-rich repeat	178..205	CDD:275380	15/26 (58%)
		leucine-rich repeat	206..233	CDD:275380	14/26 (54%)
		leucine-rich repeat	234..261	CDD:275380	13/26 (50%)
		leucine-rich repeat	262..290	CDD:275380	10/27 (37%)
rangap1	XP_012816044.1	LRR_RI	29..366	CDD:238064	153/336 (46%)
		leucine-rich repeat	59..89	CDD:275380	15/29 (52%)
		leucine-rich repeat	90..121	CDD:275380	19/30 (63%)
		leucine-rich repeat	122..151	CDD:275380	20/28 (71%)
		leucine-rich repeat	152..189	CDD:275380	16/36 (44%)
		leucine-rich repeat	190..217	CDD:275380	15/26 (58%)
		leucine-rich repeat	218..245	CDD:275380	14/26 (54%)
		leucine-rich repeat	246..273	CDD:275380	13/26 (50%)
		leucine-rich repeat	274..302	CDD:275380	10/27 (37%)
		RanGAP1_C	410..587	CDD:369547	28/154 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2476
OMA	1	1.010	-	-		QHG52895
OrthoDB	1	1.010	-	-		D1357476at2759
OrthoFinder	1	1.000	-	-		FOG0004671
OrthoInspector	1	1.000	-	-		oto105307
Panther	1	1.100	-	-	LDO	PTHR24113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1163
SonicParanoid	1	1.000	-	-		X2301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110