Protein Alignment CG10237 and CLVS1

DIOPT Version :10

• Sequence 1: NP_609967.1
• Gene: CG10237 / 35222
• FlyBaseID: FBgn0032783
• Length: 324
• Species: Drosophila melanogaster
• Sequence 2: NP_775790.1
• Gene: CLVS1 / 157807
• HGNCID: 23139
• Length: 354
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 88/301 - (29%)
• Similarity: 149/301 - (49%)
• Gaps: 21/301 - (6%)

  Fly    23 TMLSDIDQLPTLQVGDYTLQFELGEPTAQGKEVAIKELRETPERQKEASKELARLLEAETDLLYP 87
            |...|:.::..||.|       |...|.   |.|..||.|.|:...:..:::..::....|:.:.
Human    15 TWNGDLAKMTHLQAG-------LSPETI---EKARLELNENPDVLHQDIQQVRDMIITRPDIGFL 69

  Fly    88 KGNEEWLIRYLRPCKYYPESARDLIKRYYAFKVKHADVYTDLKPSNEANIFKHNILTVFP----N 148
            :.::.:::|:||..|::...|..|:.:|:.::..:.|::.:.|..:..  .|..::..||    |
Human    70 RTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPG--IKRALIDGFPGVLEN 132

  Fly   149 RDQLGRRILVLELGKRWKHKQVTLDEVFKGAVLFLEAAMLEPETQICGAVVIFDMDGLSLQQTWQ 213
            ||..||:||:| ....|...:.:..::.:..:|.||..:.:||.||.|.::|.|....|.:|..:
Human   133 RDHYGRKILLL-FAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASK 196

  Fly   214 FTPPFAKRIVDWLQDSVPLRIKAIHIVNQPKIFQVVFALFKPFLKEKLRSRIIFHGTDRESLHKY 278
            .||...|..::.||||.|.|...:|.||||.....::.|.|||||:|.|.||..||.:..|||:.
Human   197 LTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQL 261

  Fly   279 MSPKCLPAAYGGFREASRIDSDQWYQLLLKCDTEFDTINSY 319
            :.|:.||:.:||  .....|...|.:.||..|  :...|.|
Human   262 IHPEFLPSEFGG--TLPPYDMGTWARTLLGPD--YSDENDY 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10237	NP_609967.1	CRAL_TRIO_N	68..115	CDD:215024	7/46 (15%)
		CRAL_TRIO	141..290	CDD:459890	55/152 (36%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	7/45 (16%)
		SEC14	123..274	CDD:469559	57/153 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	333..354