DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab9 and RAB9B

DIOPT Version :9

Sequence 1:	NP_609966.1	Gene:	Rab9 / 35221	FlyBaseID:	FBgn0032782	Length:	256	Species:	Drosophila melanogaster
Sequence 2:	NP_057454.1	Gene:	RAB9B / 51209	HGNCID:	14090	Length:	201	Species:	Homo sapiens

Alignment Length:	194	Identity:	106/194 - (54%)
Similarity:	139/194 - (71%)	Gaps:	11/194 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KSKLLKVVILGDGGVGKSALLTRFVANRYEENNFHTIGVEFMNKDIVVDGERYTLQIWDTAGQER 73
            ||.||||::|||||||||:|:.|:|.|:::...||||||||:|:|:.|||...||||||||||||
Human     4 KSLLLKVILLGDGGVGKSSLMNRYVTNKFDSQAFHTIGVEFLNRDLEVDGRFVTLQIWDTAGQER 68

  Fly    74 FRALRTPFYRGSDICLLCYALDDRDSLKGLGVWRNEFLNYADV-DQDKFPFIVVGNKNDIPAQKR 137
            |::||||||||:|.|||.:::|||.|.:.||.|:.||:.|||| |.:.|||:|:|||.|  .:.|
Human    69 FKSLRTPFYRGADCCLLTFSVDDRQSFENLGNWQKEFIYYADVKDPEHFPFVVLGNKVD--KEDR 131

  Fly   138 QVSSDAVQQWCAEQKVACHIETSSKAATNVTDAFVLGLRQWRHMECVAEAELRQH---GDTIDL 198
            ||:::..|.||.|.....::|||:|..||||.||...:||     .:|..|..:|   |.||||
Human   132 QVTTEEAQTWCMENGDYPYLETSAKDDTNVTVAFEEAVRQ-----VLAVEEQLEHCMLGHTIDL 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab9	NP_609966.1	Rab9	8..178	CDD:206697	97/169 (57%)
Rab9	NP_609966.1	Ras	14..177	CDD:278499	92/163 (56%)
RAB9B	NP_057454.1	Rab9	3..172	CDD:206697	98/174 (56%)
RAB9B	NP_057454.1	Effector region. /evidence=ECO:0000250	36..44		6/7 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0394
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3136
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52476
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105995
Panther	1	1.100	-	-	LDO	PTHR47981
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5468
SonicParanoid	1	1.000	-	-		X2801
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810