DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RtcB and rtcb

DIOPT Version :9

Sequence 1:	NP_609965.1	Gene:	RtcB / 35220	FlyBaseID:	FBgn0032781	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001025674.1	Gene:	rtcb / 595066	XenbaseID:	XB-GENE-974751	Length:	505	Species:	Xenopus tropicalis

Alignment Length:	503	Identity:	422/503 - (83%)
Similarity:	464/503 - (92%)	Gaps:	0/503 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RPYNDELRYLEKVSDHCWRIKKGFQPNMNVEGCFYVNSRLERLMLEELKNSCRPGAVGGFLPGVK 68
            |.|||||:||:|:..:||||:|||.|||.|||.||||..||:||.|||:|:.|.||.|||||.:|
Frog     3 RSYNDELQYLDKIHKNCWRIRKGFVPNMQVEGVFYVNDPLEKLMFEELRNASRGGAAGGFLPAMK 67

  Fly    69 QIANVAALPGIVGRSIGLPDIHSGYGFAIGNMAAFDMNDPLSVVSPGGVGFDINCGVRLLRTNLY 133
            ||.||||||||:.|||||||:||||||||||||||||::|.:||||||||||||||||||||||.
Frog    68 QIGNVAALPGIIHRSIGLPDVHSGYGFAIGNMAAFDMDNPEAVVSPGGVGFDINCGVRLLRTNLD 132

  Fly   134 EKDVQPVKEQLAQSLFDHIPVGVGSKGIIPMNARDLEEALEMGMDWSLREGYVWAEDKEHCEEYG 198
            |.|||||||||||::||||||||||||:|||.|:|||||||||:||||||||.||||||||||||
Frog   133 ESDVQPVKEQLAQAMFDHIPVGVGSKGVIPMGAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYG 197

  Fly   199 RMLNADPAKVSMRAKKRGLPQLGTLGAGNHYAEIQVVDEIYDKWSASKMGIEEKGQVVVMIHSGS 263
            |||.|||:|||.:||||||||||||||||||||:||||:|||:::|.||||:.||||.|||||||
Frog   198 RMLQADPSKVSSKAKKRGLPQLGTLGAGNHYAEVQVVDDIYDEYAAKKMGIDHKGQVCVMIHSGS 262

  Fly   264 RGFGHQVATDALVQMEKAMKRDKIETNDRQLACARINSVEGQDYLKAMAAAANFAWVNRSSMTFL 328
            ||.||||||||||.||||||||||..||||||||||:|.|||||||.||||.|:|||||||||||
Frog   263 RGLGHQVATDALVAMEKAMKRDKITVNDRQLACARISSAEGQDYLKGMAAAGNYAWVNRSSMTFL 327

  Fly   329 TRQAFAKMFNTTPDDLDMHVIYDVSHNIAKVENHMVDGKERKLLVHRKGSTRAFPPHHPLIPVDY 393
            |||||:|:|||||||||:||||||||||||||.|:|||||:.|||||||||||||||||||||||
Frog   328 TRQAFSKVFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKEKTLLVHRKGSTRAFPPHHPLIPVDY 392

  Fly   394 QLTGQPVLVGGTMGTCSYVLTGTEQGMQETFGSTCHGAGRALSRAKSRRNLDYKDVLDKLDQLGI 458
            ||||||||:||||||||||||||:|||.||||:|||||||||||||||||||::||||||..|||
Frog   393 QLTGQPVLIGGTMGTCSYVLTGTDQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLDKLADLGI 457

  Fly   459 AIRVASPKLVMEEAPESYKDVTDVVDTCHAAGISKKCIKMRPIAVIKG 506
            |||||||||||||||||||:|||||:|||.||||||.||:||||||||
Frog   458 AIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RtcB	NP_609965.1	RtcB	67..506	CDD:224604	378/438 (86%)
RtcB	NP_609965.1	RtcB	67..506	CDD:279481	378/438 (86%)
rtcb	NP_001025674.1	RtcB	68..505	CDD:307338	377/436 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	781	1.000	Domainoid score	I82
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36344
Inparanoid	1	1.050	877	1.000	Inparanoid score	I399
OMA	1	1.010	-	-		QHG60604
OrthoDB	1	1.010	-	-		D203128at33208
OrthoFinder	1	1.000	-	-		FOG0004814
OrthoInspector	1	1.000	-	-		otm48883
Panther	1	1.100	-	-	LDO	PTHR11118
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2780
SonicParanoid	1	1.000	-	-		X3956
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110