Protein Alignment Alp12 and Alpi

DIOPT Version :10

• Sequence 1: NP_609963.1
• Gene: Alp12 / 35218
• FlyBaseID: FBgn0032779
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001074551.1
• Gene: Alpi / 76768
• MGIID: 1924018
• Length: 554
• Species: Mus musculus
• Alignment Length: 512
• Identity: 189/512 - (36%)
• Similarity: 271/512 - (52%)
• Gaps: 46/512 - (8%)

  Fly   105 LPKEQKE---WYDQGIDELQKAVSRQFNRRRAKNVILFVGDGMGPNTVTAARILGVKEEG----- 161
            :|.|::.   |..:..:.|..|...|..:..|||:|:|:|||||..||||.|||..:.||
Mouse    22 IPAEEENPAFWNKKAAEALDAAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPE 86

  Fly   162 -LLRWEQFPDMGLLKTYCADKQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKEDHHV 225
             .|..:.||.|.|.|||..|:|||||..||||...|||.||:|.|:.|...|..|:.:.  .:.|
Mouse    87 TPLAMDLFPYMALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGLSAAARLDQCNTTF--GNEV 149

  Fly   226 QTILKWAQVDGMRTGFVTTTRVTHATPAALYAHVPDRRWECESGMPAEAQGQGCMDIARQLIEQP 290
            .:::..|:..|...|.||||||.||:||..|||..:|.|..::.|||.|...||.|||.|||
Mouse   150 FSVMYRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDAEMPASALQDGCKDIATQLI--- 211

  Fly   291 TGQSINVIMGGGRQMLVSDVTGSAADPLDT-WAGQSKDGRDLIRDWRLKKADEGVSHAVVQNNRE 354
            :...|:||:||||:.:....|.....|.|: .:|...|.::|::.|..|.          |..|.
Mouse   212 SNMDIDVILGGGRKFMFPKGTPDPEYPSDSNQSGTRLDDQNLVQTWLSKH----------QGARY 266

  Fly   355 LWNLN-----GQD--VDYVLGIFANGHLMYDHERDRS-DAGMPSLSNMTLKALEVLGNSDKGFLL 411
            :||.:     .||  |.:::|:|....:.||..|:.| |   |||:.||..|:.:|..:.:||.|
Mouse   267 VWNRSELIQASQDPAVTHLMGLFEPTEMKYDANRNPSVD---PSLAEMTEVAVRMLSRNPQGFYL 328

  Fly   412 VVEAGLIDQAHHRGNARKALSEVLELNAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPD 476
            .||.|.|||.||.|.|..||:|.:..::|:|.........|    ||:::||||||.....|:..
Mouse   329 FVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKD----TLILITADHSHVFAFGGYTL 389

  Fly   477 RGSSILGLAGNSKTEGTPYTTLTYGTSYQGFQVDPQTQSRKDPTADDITAWEYTQQAAINTDENL 541
            ||:||.|||.....:...||::.||.. .|:::  ::.:|.:.|........|.||||:......
Mouse   390 RGTSIFGLAPLKALDDKSYTSILYGNG-PGYEL--KSGNRPNVTEAQSVDPNYKQQAAVPLSSET 451

  Fly   542 HGGSDVTIHADGAMSYLFHGVHEQSYVAHAISYALRIGRFRDSSIAETLAE---LTP 595
            |||.||.|.|.|..::|.|||.||:|:||.:::|..:..:.|..:|....:   :||
Mouse   452 HGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPAGQSPVITP 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp12	NP_609963.1	ALP_like	134..579	CDD:474031	178/459 (39%)
Alpi	NP_001074551.1	Alk_phosphatase	53..488	CDD:395188	179/459 (39%)