DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp12 and Alp10

DIOPT Version :9

Sequence 1:	NP_001188848.1	Gene:	Alp12 / 35218	FlyBaseID:	FBgn0032779	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	213/559 - (38%)
Similarity:	289/559 - (51%)	Gaps:	76/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LISVVFSALLITAMCIGFVVHYGMSGDVGDMETVSYWP----------VDLPKEQKEWYDQG--- 116
            ||...|:.|:|.|           ..|:.|.:..:..|          :|...:.:.|:|:.
  Fly     6 LILCFFALLVIQA-----------RSDLADDQEHAQHPRLQSSRDFEALDEELDTRFWHDKAQSI 59

  Fly   117 -IDELQKAVSRQFNRRRAKNVILFVGDGMGPNTVTAARILGVKEEGLLRWEQFPDMGLLKTYCAD 180
             .|:|  |..::.|..||||||||:||||..:|:.|.|.........:.:|:||.:||.|||..:
  Fly    60 LADKL--AGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGDSNKQVFFEKFPYLGLSKTYAVN 122

  Fly   181 KQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKEDHHVQTILKWAQVDGMRTGFVTTT 245
            ::.|||.:||||...|||.||.|.||:|.|..|:|..:  ...|||:|.:|||..|...|.|||.
  Fly   123 ERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTN--SSSHVQSIGQWAQEAGKWAGLVTTA 185

  Fly   246 RVTHATPAALYAHVPDRRWECESGMPAEAQGQGC-----MDIARQLIEQPTGQSINVIMGGGRQM 305
            |||||:||.:||||.:|.||.:    .|.....|     .||||||:|.|.||.:.|||||||..
  Fly   186 RVTHASPAGVYAHVSERNWEHD----GEIISSKCSPDVNTDIARQLVEWPVGQELRVIMGGGRSY 246

  Fly   306 L----VSDVTGSAADPLDTWAGQSKDGRDLIRDWRLKKADEGVSHAVVQNNRELWNLNG------ 360
            .    ..|.||.        :|...||||||.|||..|..:|.      ..:.:|:|.|
  Fly   247 FRDQSQHDETGV--------SGLRTDGRDLISDWREIKKQQGA------EGKYVWSLKGLKETDI 297

  Fly   361 QDVDYVLGIFANGHLMY--DHERDRSDAGMPSLSNMTLKALEVLGNSDKGFLLVVEAGLIDQAHH 423
            ...||:||:|...||.|  |..|...:...||||:||..|:::|..:::|:.|.||:|.||.|||
  Fly   298 SKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEEGYFLFVESGRIDMAHH 362

  Fly   424 RGNARKALSEVLELNAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPDRGSSILGLAGNS 488
            ...|.|||.:..|..||||..   .|.:|. ::||::||:||||:::|||:|.|..:||.||.|.
  Fly   363 ATKAMKALEDTEEFAAAVELA---RKMTDE-EDTLIVVTSDHSHTMSINGYPYRRQNILSLAPNL 423

  Fly   489 KTEGTPYTTLTYGTSYQGFQVDPQTQSRKDPTAD----DITAWEYTQQAAINTDENLHGGSDVTI 549
            ..:..|:|.|:|... .||.   .|.|.||...|    |.|:.|:..||.:......||..||.:
  Fly   424 ADDELPFTILSYANG-PGFD---DTYSTKDGRIDLSHADTTSAEFEFQATVPLSSETHGAEDVGV 484

  Fly   550 HADGAMSYLFHGVHEQSYVAHAISYALRIGRFRDSSIAE 588
            .|.|...:||.|.:|||.:...::||..||.|....|.|
  Fly   485 FASGPFEHLFTGNYEQSAIPAMMAYAANIGPFAKDKINE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp12	NP_001188848.1	ALP_like	134..579	CDD:304875	190/465 (41%)
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	194/483 (40%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	190/463 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466668
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.800