DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp12 and ALPG

DIOPT Version :9

Sequence 1:	NP_001188848.1	Gene:	Alp12 / 35218	FlyBaseID:	FBgn0032779	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_112603.2	Gene:	ALPG / 251	HGNCID:	441	Length:	532	Species:	Homo sapiens

Alignment Length:	509	Identity:	188/509 - (36%)
Similarity:	271/509 - (53%)	Gaps:	50/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LPKEQKE---WYDQGIDELQKAVSRQFNRRRAKNVILFVGDGMGPNTVTAARIL-GVKEEGL--- 162
            :|.|::.   |..|..:.|..|...|..:..|||:|:|:|||||.:|||||||| |.|::.|
Human    21 IPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPE 85

  Fly   163 --LRWEQFPDMGLLKTYCADKQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKEDHHV 225
              |..::||.:.|.|||..||.||||.:||||...|||.|::|.|:.|......|:.:  ..:.|
Human    86 TFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTT--RGNEV 148

  Fly   226 QTILKWAQVDGMRTGFVTTTRVTHATPAALYAHVPDRRWECESGMPAEAQGQGCMDIARQLIEQP 290
            .:::..|:..|...|.||||||.||:||..|||..:|.|..::.:||.|:.:||.|||.|||
Human   149 ISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLI--- 210

  Fly   291 TGQSINVIMGGGRQMLVSDVTGSAADPLD-TWAGQSKDGRDLIRDWRLKKADEGVSHAVVQNNRE 354
            :...|:||:||||:.:....|.....|.| :..|...||::|:::|..|.          |..|.
Human   211 SNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKH----------QGARY 265

  Fly   355 LWNLN-------GQDVDYVLGIFANGHLMYDHERDRS-DAGMPSLSNMTLKALEVLGNSDKGFLL 411
            :||..       ...|.:::|:|..|.:.|:..||.: |   |||..||..||.:|..:.:||.|
Human   266 VWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLD---PSLMEMTEAALLLLSRNPRGFFL 327

  Fly   412 VVEAGLIDQAHHRGNARKALSEVLELNAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPD 476
            .||.|.||..||...|.:||:|.:..:.|:|.........|    ||.:|||||||..:..|:|.
Human   328 FVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEED----TLSLVTADHSHVFSFGGYPL 388

  Fly   477 RGSSILGLAGNSKTEGTPYTTLTYGTSYQGFQVDPQTQSRKDPTADDITAWEYTQQAAINTDENL 541
            |||||.|||.....:...||.|.||.. .|:.:  :..:|.|.|..:..:.||.||:|:..|...
Human   389 RGSSIFGLAPGKARDRKAYTVLLYGNG-PGYVL--KDGARPDVTESESGSPEYRQQSAVPLDGET 450

  Fly   542 HGGSDVTIHADGAMSYLFHGVHEQSYVAHAISYALRIGRFRDSSIAETLAELTP 595
            |.|.||.:.|.|..::|.|||.||:::||.:::|..:..:       |..:|.|
Human   451 HAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPY-------TACDLAP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp12	NP_001188848.1	ALP_like	134..579	CDD:304875	177/459 (39%)
ALPG	NP_112603.2	PRK10518	25..475	CDD:236706	179/474 (38%)
		Alk_phosphatase	52..487	CDD:278666	178/459 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..443		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.660