Protein Alignment Alp12 and ALPP

DIOPT Version :10

• Sequence 1: NP_609963.1
• Gene: Alp12 / 35218
• FlyBaseID: FBgn0032779
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001623.3
• Gene: ALPP / 250
• HGNCID: 439
• Length: 535
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 188/509 - (36%)
• Similarity: 273/509 - (53%)
• Gaps: 50/509 - (9%)

  Fly   105 LPKEQKE---WYDQGIDELQKAVSRQFNRRRAKNVILFVGDGMGPNTVTAARIL-GVKEEGL--- 162
            :|.|::.   |..:..:.|..|...|..:..|||:|:|:|||||.:|||||||| |.|::.|
Human    24 IPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPE 88

  Fly   163 --LRWEQFPDMGLLKTYCADKQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKEDHHV 225
              |..::||.:.|.|||..||.||||.:||||...|||.|::|.|:.|......|:.:  ..:.|
Human    89 IPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTT--RGNEV 151

  Fly   226 QTILKWAQVDGMRTGFVTTTRVTHATPAALYAHVPDRRWECESGMPAEAQGQGCMDIARQLIEQP 290
            .:::..|:..|...|.||||||.||:||..|||..:|.|..::.:||.|:.:||.|||.|||
Human   152 ISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLI--- 213

  Fly   291 TGQSINVIMGGGRQMLVSDVTGSAADPLD-TWAGQSKDGRDLIRDWRLKKADEGVSHAVVQNNRE 354
            :...|:||:||||:.:....|.....|.| :..|...||::|:::|..|:          |..|.
Human   214 SNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKR----------QGARY 268

  Fly   355 LWNLN-------GQDVDYVLGIFANGHLMYDHERDRS-DAGMPSLSNMTLKALEVLGNSDKGFLL 411
            :||..       ...|.:::|:|..|.:.|:..||.: |   |||..||..||.:|..:.:||.|
Human   269 VWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLD---PSLMEMTEAALRLLSRNPRGFFL 330

  Fly   412 VVEAGLIDQAHHRGNARKALSEVLELNAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPD 476
            .||.|.||..||...|.:||:|.:..:.|:|.........|    ||.:|||||||..:..|:|.
Human   331 FVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEED----TLSLVTADHSHVFSFGGYPL 391

  Fly   477 RGSSILGLAGNSKTEGTPYTTLTYGTSYQGFQVDPQTQSRKDPTADDITAWEYTQQAAINTDENL 541
            |||||.|||.....:...||.|.||.. .|:.:  :..:|.|.|..:..:.||.||:|:..||..
Human   392 RGSSIFGLAPGKARDRKAYTVLLYGNG-PGYVL--KDGARPDVTESESGSPEYRQQSAVPLDEET 453

  Fly   542 HGGSDVTIHADGAMSYLFHGVHEQSYVAHAISYALRIGRFRDSSIAETLAELTP 595
            |.|.||.:.|.|..::|.|||.||:::||.:::|..:..:       |..:|.|
Human   454 HAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPY-------TACDLAP 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp12	NP_609963.1	ALP_like	134..579	CDD:474031	178/459 (39%)
ALPP	NP_001623.3	Alk_phosphatase	55..490	CDD:395188	179/459 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..449		8/23 (35%)