Protein Alignment Alp12 and ALPI

DIOPT Version :9

• Sequence 1: NP_001188848.1
• Gene: Alp12 / 35218
• FlyBaseID: FBgn0032779
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 188/503 - (37%)
• Similarity: 272/503 - (54%)
• Gaps: 38/503 - (7%)

  Fly   105 LPKEQKE---WYDQGIDELQKAVSRQFNRRRAKNVILFVGDGMGPNTVTAARILGVKEEGL---- 162
            :|.|::.   |..|..:.|..|...|..::.|||:|||:|||:|..||||.|||..::.|.
Human    21 IPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPE 85

  Fly   163 --LRWEQFPDMGLLKTYCADKQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKEDHHV 225
              |..::||.:.|.|||..|:|||||.:||||...|||.|::|.|:.|......|:.:  ..:.|
Human    86 TPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTT--RGNEV 148

  Fly   226 QTILKWAQVDGMRTGFVTTTRVTHATPAALYAHVPDRRWECESGMPAEAQGQGCMDIARQLIEQP 290
            .:::..|:..|...|.||||||.||:||..|||..:|.|..::.|||.|:.:||.|||.|||
Human   149 ISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLI--- 210

  Fly   291 TGQSINVIMGGGRQMLVSDVTGSAADPLD-TWAGQSKDGRDLIRDWRLKKADEGVSHAVVQNNRE 354
            :...|:||:||||:.:....|.....|.| :..|...||::|:::|..|  .:|..:  |.|..|
Human   211 SNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAK--HQGAWY--VWNRTE 271

  Fly   355 LWNLN-GQDVDYVLGIFANGHLMYDHERDRS-DAGMPSLSNMTLKALEVLGNSDKGFLLVVEAGL 417
            |...: .|.|.:::|:|..|...|:..||.: |   |||..||..||.:|..:.:||.|.||.|.
Human   272 LMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLD---PSLMEMTEAALRLLSRNPRGFYLFVEGGR 333

  Fly   418 IDQAHHRGNARKALSEVLELNAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPDRGSSIL 482
            ||..||.|.|.:||:|.:..:.|:|.........|    ||.:|||||||..:..|:..|||||.
Human   334 IDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEED----TLTLVTADHSHVFSFGGYTLRGSSIF 394

  Fly   483 GLAGNSKTEGTPYTTLTYGTSYQGFQVDPQTQSRKDPTADDITAWEYTQQAAINTDENLHGGSDV 547
            |||.:...:...||::.||.. .|:..:  :..|.|....:..:.:|.||||:......|||.||
Human   395 GLAPSKAQDSKAYTSILYGNG-PGYVFN--SGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDV 456

  Fly   548 TIHADGAMSYLFHGVHEQSYVAHAISYALRIGRFRDSSIAETLAELTP 595
            .:.|.|..::|.|||.|||:|||.:::|..:..:       |..:|.|
Human   457 AVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY-------TACDLAP 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp12	NP_001188848.1	ALP_like	134..579	CDD:304875	177/453 (39%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	178/453 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.660