DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp12 and Alppl2

DIOPT Version :9

Sequence 1:	NP_001188848.1	Gene:	Alp12 / 35218	FlyBaseID:	FBgn0032779	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_031459.3	Gene:	Alppl2 / 11650	MGIID:	108009	Length:	529	Species:	Mus musculus

Alignment Length:	521	Identity:	181/521 - (34%)
Similarity:	271/521 - (52%)	Gaps:	59/521 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PVDLPKEQKE---WYDQGIDELQKAVSRQFNRRRAKNVILFVGDGMGPNTVTAARILGVKEEG-- 161
            |..:|.|::.   |..:..:.|..|...:..:..|||:::.:|||||.:||||.|||..:::|
Mouse    17 PSVIPVEEENPAFWNRKAAEALDAAKKLKPIQTSAKNLVILMGDGMGVSTVTATRILKGQQQGHL 81

  Fly   162 ----LLRWEQFPDMGLLKTYCADKQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKED 222
                .|..::||.|.|.|||..|||:|||..|.||...|||.|.:..|:.|......|:.:.  .
Mouse    82 GPETQLAMDRFPHMALSKTYNTDKQIPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTW--G 144

  Fly   223 HHVQTILKWAQVDGMRTGFVTTTRVTHATPAALYAHVPDRRWECESGMPAEAQGQGCMDIARQLI 287
            :.|.:::..|:..|...|.||||.|.||:||..|||..:|.|..::.|||.|...||.||:.|||
Mouse   145 NEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRGWYSDAQMPASALQDGCKDISTQLI 209

  Fly   288 EQPTGQSINVIMGGGRQMLVSDVTGSAADPLDT-WAGQSKDGRDLIRDWRLKKADEGVSHAVVQN 351
               :...|:||:||||:.:....|.....|.|| .||...|||:|:::|..|.          |.
Mouse   210 ---SNMDIDVILGGGRKFMFPKGTPDQEYPTDTKQAGTRLDGRNLVQEWLAKH----------QG 261

  Fly   352 NRELWN--------LNGQDVDYVLGIFANGHLMYDHERDRSDAGMPSLSNMTLKALEVLGNSDKG 408
            .|.:||        || :.|.:::|:|....:.|:..||  .|..|||:.||..|:.:|..:.||
Mouse   262 ARYVWNRSELIQASLN-RSVTHLMGLFEPNDMKYEIHRD--PAQDPSLAEMTEVAVRMLSRNPKG 323

  Fly   409 FLLVVEAGLIDQAHHRGNARKALSEVLELNAAVESTLSFLKSSDRL---DETLVIVTADHSHSLT 470
            |.|.||.|.||..||...|.:||:|.:..::||:       .:|:|   .:|:::|||||||..:
Mouse   324 FYLFVEGGRIDHGHHETVAYRALTEAVMFDSAVD-------KADKLTSEQDTMILVTADHSHVFS 381

  Fly   471 INGHPDRGSSILGLAGNSKTEGTPYTTLTYGTS-----YQGFQVDPQTQSRKDPTADDITAWEYT 530
            ..|:..||:||.|||.....:|..:|::.||..     :.|.:.|...:...:||        |.
Mouse   382 FGGYTQRGASIFGLAPFKAEDGKSFTSILYGNGPGYKLHNGARADVTEEESSNPT--------YQ 438

  Fly   531 QQAAINTDENLHGGSDVTIHADGAMSYLFHGVHEQSYVAHAISYALRIGRFRDSSIAETLAELTP 595
            ||||:......|.|.||.|.|.|..::|.|||.||:|:||.:::|..:..:.|..:|....:.:.
Mouse   439 QQAAVPLSSETHSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAACLEPYTDCGLASPAGQSSA 503

  Fly   596 I 596
            :
Mouse   504 V 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp12	NP_001188848.1	ALP_like	134..579	CDD:304875	172/467 (37%)
Alppl2	NP_031459.3	Alk_phosphatase	51..486	CDD:333956	173/467 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847854
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650