DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and LHX4

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_203129.1	Gene:	LHX4 / 89884	HGNCID:	21734	Length:	390	Species:	Homo sapiens

Alignment Length:	178	Identity:	59/178 - (33%)
Similarity:	77/178 - (43%)	Gaps:	29/178 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 PRCAYCNGAILDKCV-TALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNG 468
            |:||.||..||||.: ..||:.||:....||.|..|..:..| .|.|..||:.|:|:.|..||..
Human    28 PQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCF-SRAGSVYCKEDFFKRFGTKCTA 91

  Fly   469 CNRAIMENYI--SALNSQWHPDCFVCRDC-RQPFQGGSFF-DHEGLPYCETHYH-AKRGSLC-AG 527
            |.:.|....:  .|.:..:|..||.|..| ||...|..|: ..:|...|:..|. ||:.... ||
Human    92 CQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAG 156

  Fly   528 CSKPITGRCITAMFKKFHPEHFVCAFCLKQLN--KGTFKEQKDKPYCH 573
            ..:|.|  .|||                |||.  |..:| ...||..|
Human   157 AKRPRT--TITA----------------KQLETLKNAYK-NSPKPARH 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830
		LIM2_Paxillin_like	407..458	CDD:188723	21/51 (41%)
		LIM3_Paxillin_like	466..518	CDD:188724	15/55 (27%)
		LIM4_Paxillin	525..576	CDD:188795	15/52 (29%)
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852	21/51 (41%)
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	15/54 (28%)
		Homeobox	160..213	CDD:306543	13/45 (29%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536	161..181		9/38 (24%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305\|PubMed:28473536	199..211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910