DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax and PXL1

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_013016.4	Gene:	PXL1 / 853965	SGDID:	S000001798	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	750	Identity:	148/750 - (19%)
Similarity:	233/750 - (31%)	Gaps:	259/750 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDRTMYG----KIDPGARQPYRTARSKGILPGY-------------ALLADLQNSVPGQPQQPQP 48
            |..::||    ||:|..|  |:||..:.   |:             |....||.||...|...|.
Yeast     1 MYNSIYGSPFPKINPKVR--YKTALERA---GFDTKPRNPFSSQRNASTGSLQASVKSPPITRQR 60

  Fly    49 QYGTVQPKHQALQQQQFVDNTPGYGSLRGKAQ---PQVYQEHYSVETRSPTAGHDFNGSSTTPG- 109
            ...........::......:...|.|::|::.   |.|.:   :.|.||.|...:.|.:|:.|.
Yeast    61 NVSAAPSVPVTMKSAYTASSKSAYSSVKGESDIYPPPVLE---NSERRSVTPPKNSNFTSSRPSD 122

  Fly   110 -----------------YANQGSLPRQAA--GAS--------------------------TGLSE 129
                             :..:..|.|||.  .||                          .|.:|
Yeast   123 ISRSISRPSERASQEDPFRFERDLDRQAEQYAASRHTCKSPANKEFQAADNFPFNFEQEDAGNTE 187

  Fly   130 LDSLLQDLQKIDVPVNYSTPVSKYNTMN--------------------------SYATVEERPSV 168
            .:..|..:::..:.:..:...|..|:||                          |....|:...:
Yeast   188 REQDLSPIERSFMMLTQNDTASVVNSMNQTDNRGVLDQKLGKEQQKEESSIEYESEGQQEDENDI 252

  Fly   169 DSLLKE--------LDNAHIY-AVPNGSAHKSPTPGRHVTITV-RETKTEKLT--------GPDG 215
            :||..|        |:|..:. ..|.....:..|..:...|.| ||:.|..||        .||.
Yeast   253 ESLNFEPDPKLQMNLENEPLQDDFPEAKQEEKNTEPKIPEINVTRESNTPSLTMNALDSKIYPDD 317

  Fly   216 PVGTVEEQIVQQKDSYTPNHA-----------------VPGQQVHQAYTSQATKELDDLMASLSD 263
            ....:|....|:....:.:..                 ...:.|...||: ...:::.|:|.|.|
Yeast   318 NFSGLESSKEQKSPGVSSSSTKVEDLSLDGLNEKRLSITSSENVETPYTA-TNLQVEQLIAQLDD 381

  Fly   264 FKVS-------NGT--NGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDS 319
            ..:|       ||.  |.:...:...:.||..    ::.|.     |....:||   :|:||::|
Yeast   382 VSLSRNAKLDMNGNCLNAVDRKASRFKKSSAY----LSGYP-----SMDIPVTQ---QTSIVQNS 434

  Fly   320 REDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQE---- 380
                        ..|:|||.: .|.||..:. :.|   ...|..|.|  |..:.....:.|
Yeast   435 ------------NTNLSRQTI-LVDKGDVDE-DAP---SESTTNGGT--PIFYKFKQSNVEYSNN 480

  Fly   381 --LGTRNFFERDGFPYCEP----------------------DYHNL-------FSPRCAYCNGAI 414
              :|::..| |...|..|.                      |.|.|       :|....|
Yeast   481 EGMGSQETF-RTKLPTIEALQLQHKRNITDLREEIDNSKSNDSHVLPNGGTTRYSSDADY----- 539

  Fly   415 LDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIMENYIS 479
              |....::..:......|..||.        |..||        .||:.|.|
Yeast   540 --KETEPIEFKYPPGEGPCRACGL--------EVTGK--------RMFSKKEN------------ 574

  Fly   480 ALNSQWHPDCFVCRDCRQPFQGGSFFDHEGL------PYCETHYHAKRGSLCAGCSKPITGRCI- 537
            .|:.|||.:||.|.:|     |..|..|...      |||:.|||.:..|:|..||..|.|.|:
Yeast   575 ELSGQWHRECFKCIEC-----GIKFNKHVPCYILGDEPYCQKHYHEENHSICKVCSNFIEGECLE 634

  Fly   538 TAMFKKFHPEHFVCAFCLKQLNKGTFKEQKDKPYC 572
            ....::||.:...|..|...:....:....:.|.|
Yeast   635 NDKVERFHVDCLNCFLCKTAITNDYYIFNGEIPLC 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	12/79 (15%)
		LIM2_Paxillin_like	407..458	CDD:188723	8/50 (16%)
		LIM3_Paxillin_like	466..518	CDD:188724	16/57 (28%)
		LIM4_Paxillin	525..576	CDD:188795	11/48 (23%)
PXL1	NP_013016.4	LIM1_UF1	556..614	CDD:188783	25/90 (28%)
PXL1	NP_013016.4	LIM	621..672	CDD:259829	11/48 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910