DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and AJUBA

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_116265.1	Gene:	AJUBA / 84962	HGNCID:	20250	Length:	538	Species:	Homo sapiens

Alignment Length:	603	Identity:	141/603 - (23%)
Similarity:	208/603 - (34%)	Gaps:	176/603 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PGYALLADLQNSVPGQPQQPQPQYGTVQPKHQALQQQQFVDNTPGYGSLRGKAQPQVYQEHYSVE 91
            ||...|:.|     |.|::..|:..|..|..:.|:..:                          |
Human    33 PGKGRLSGL-----GGPRKSGPRGATGGPGDEPLEPAR--------------------------E 66

  Fly    92 TRSPTAGHDFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKIDVPVNYSTPVSKYNTM 156
            ..|..|..:..||...|.|  :||.|  |....|....|...|....:::......:|.|.:  .
Human    67 QGSLDAERNQRGSFEAPRY--EGSFP--AGPPPTRALPLPQSLPPDFRLEPTAPALSPRSSF--A 125

  Fly   157 NSYATVEERPSV--DSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKLTGPDGPVGT 219
            :|.|:...:||.  .|||  ||.|.    ..|:....|...|...|::...:......|.||. .
Human   126 SSSASDASKPSSPRGSLL--LDGAG----AGGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPC-L 183

  Fly   220 VEEQIVQQKDSYTPNHAVPG--QQVHQAYTSQATKELDDLMA----------SLSDFKVSNGT-- 270
            ....:......|:|. .||.  .::|.|        ||.|.|          |...:..:.|:
Human   184 FGPPLAGAPAGYSPG-GVPSAYPELHAA--------LDRLYAQRPAGFGCQESRHSYPPALGSPG 239

  Fly   271 ----NGIG-------NGSHPQQHSSTVQHQTVTDYARPNKGSQ-QAHLTQTIEETTIVEDSRE-- 321
                .|:|       .|:.|.:||       ||.|.....|:: |..||..: ..|:....||
Human   240 ALAGAGVGAAGPLERRGAQPGRHS-------VTGYGDCAVGARYQDELTALL-RLTVGTGGREAG 296

  Fly   322 ----------DQLDSMLGNL-----QANMSRQGVNTVQKGCCNACEKPIVGQ--VITALGKTWHP 369
                      ..|:...|..     :|.|..........|.|..|.|.|.||  ...||...:|.
Human   297 ARGEPSGIEPSGLEEPPGPFVPEAARARMREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHT 361

  Fly   370 EHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFS------PRCAYCNGAILDKCVTALDKTWHT 428
            :.|.|..|.:.|..:.|:..:|..|||.||  |||      .:|..|...||:|.:.|:.|::|.
Human   362 QCFVCCSCGRTLRCKAFYSVNGSVYCEEDY--LFSGFQEAAEKCCVCGHLILEKILQAMGKSYHP 424

  Fly   429 EHFFCAQCGQQFGEEGFHERDGKP---------YCRNDYFEMFAPKCNGCNRAIMEN-------Y 477
            ..|.|..|.:..        ||.|         ||..||.:.:||||..|.:.|:.:       .
Human   425 GCFRCIVCNKCL--------DGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVR 481

  Fly   478 ISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFK 542
            :.:::..:|.:|:.|.|||....     |.||               |  |..|:.|
Human   482 VISMDRDYHFECYHCEDCRMQLS-----DEEG---------------C--CCFPLDG-------- 516

  Fly   543 KFHPEHFVCAFC-LKQLN 559
                 |.:|..| :::||
Human   517 -----HLLCHGCHMQRLN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	19/53 (36%)
		LIM2_Paxillin_like	407..458	CDD:188723	16/59 (27%)
		LIM3_Paxillin_like	466..518	CDD:188724	12/58 (21%)
		LIM4_Paxillin	525..576	CDD:188795	9/36 (25%)
AJUBA	NP_116265.1	PreLIM	1..335		75/362 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..172		40/181 (22%)
		PHA03418	<18..>103	CDD:177646	23/104 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	280..288		2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..315		3/23 (13%)
		LIM1_Ajuba_like	338..391	CDD:188738	18/52 (35%)
		LIM2_Ajuba_like	403..455	CDD:188741	16/59 (27%)
		LIM3_Ajuba_like	463..524	CDD:188822	18/95 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910