DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and SYNPO2L

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001107605.1	Gene:	SYNPO2L / 79933	HGNCID:	23532	Length:	977	Species:	Homo sapiens

Alignment Length:	304	Identity:	69/304 - (22%)
Similarity:	96/304 - (31%)	Gaps:	97/304 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YRTARSKGILPGYA-------------------LLADLQNSVPGQPQQPQPQYGTVQPKHQALQQ 62
            |..|.|:.:.||.|                   |.|.|:.|  .:|:.|.|..|..:|  .:.::
Human   551 YIPAPSRPVTPGGAPEPPAPPSAAAMTSTASIFLSAPLRPS--ARPEAPAPGPGAPEP--PSARE 611

  Fly    63 QQFVDNTPGYGSLRGKAQPQVYQEHYSVETRSP--TAGHDFNGSSTTPG----YANQGSLPRQAA 121
            |:.  :.|.       |:..:.||.....||..  ..|.:...:|..|.    ..|....|| |.
Human   612 QRI--SVPA-------ARTGILQEARRRGTRKQMFRPGKEETKNSPNPELLSLVQNLDEKPR-AG 666

  Fly   122 GASTGLSELDSLLQDLQKIDVPVNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNG 186
            ||.:|..| |:|....:    ..|:..||.    ..||.|:   |.|..           ..|..
Human   667 GAESGPEE-DALSLGAE----ACNFMQPVG----ARSYKTL---PHVTP-----------KTPPP 708

  Fly   187 SAHKSPTPGRHVTITVRETKTEKLTGPDGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQAT 251
            .|.|:|.|           .|.|...|..|              ..|:..:....|:.|.:|...
Human   709 MAPKTPPP-----------MTPKTPPPVAP--------------KPPSRGLLDGLVNGAASSAGI 748

  Fly   252 KELDDLMA----------SLSDFKVSNGTNGIGNGSHPQQHSST 285
            .|...|..          |.:|..|..||.|.|.|..|:..|.|
Human   749 PEPPRLQGRGGELFAKRQSRADRYVVEGTPGPGLGPRPRSPSPT 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
SYNPO2L	NP_001107605.1	PDZ_signaling	6..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..677		34/140 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..802		29/135 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	922..950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900