DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and ARHGAP28

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001353159.1	Gene:	ARHGAP28 / 79822	HGNCID:	25509	Length:	729	Species:	Homo sapiens

Alignment Length:	195	Identity:	40/195 - (20%)
Similarity:	70/195 - (35%)	Gaps:	43/195 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NHAVPGQQVHQAYTSQATKELDDLMASLSDF-----KVSNGTNGIGNGSHPQQHSSTVQHQTVTD 293
            |..:..:.:|....|::..|.....||:.||     .:.:.:.| |....|....:.|
Human    51 NRMLSNESLHPPAFSRSNSEASVDSASMEDFWREIESIKDSSMG-GQEEPPPAEVTPV------- 107

  Fly   294 YARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQK------GCCNACE 352
                ::|..:|...|.:..:|::....|:...::|..|    :|.....|||      ......:
Human   108 ----DEGELEAEWLQDVGLSTLISGDEEEDGKALLSTL----TRTQAAAVQKRYHTYTQTMRKKD 164

  Fly   353 KPIVGQVITALGKTWHPEHFTC-NHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILD 416
            |..:..|....|.:..|...|| ||.:|..||:.  ||:             .||....:|::.|
Human   165 KQSIRDVRDIFGVSESPPRDTCGNHTNQLDGTKE--ERE-------------LPRVIKTSGSMPD 214

Fly 417 416
Human 215 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	13/52 (25%)
		LIM2_Paxillin_like	407..458	CDD:188723	2/10 (20%)
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
ARHGAP28	NP_001353159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..105		10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..236		15/54 (28%)
		RhoGAP_ARHGAP18	377..588	CDD:239856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1093
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030