DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and ZYX

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001010972.1	Gene:	ZYX / 7791	HGNCID:	13200	Length:	572	Species:	Homo sapiens

Alignment Length:	470	Identity:	109/470 - (23%)
Similarity:	172/470 - (36%)	Gaps:	103/470 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PRQ-AAGASTGLSELDSLLQDLQKID----------VPVNYSTPVSKYNT-------------MN 157
            ||: .:.....:..|.|||.|:.|.|          ||...:||.|..::             ..
Human   137 PREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWK 201

  Fly   158 SYATVEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVR-ETKTEKL--TGPDGPVGT 219
            |.::.:..|.|.:..:.....|:        ...|.|...|.:.|: :|:...|  |.|.||..:
Human   202 SPSSSQPLPQVPAPAQSQTQFHV--------QPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPAS 258

  Fly   220 VEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQ--- 281
                        :|..|.....|...:|..|:             |.|.|..| |:||.|.|
Human   259 ------------SPAPAPKFSPVTPKFTPVAS-------------KFSPGAPG-GSGSQPNQKLG 297

  Fly   282 HSSTVQHQTVT------DYAR----------------PNKGSQQAHLTQTIEETTIVEDSREDQL 324
            |...:...|.:      .||:                |.:...|..........|:.|....:||
Human   298 HPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQL 362

  Fly   325 DSMLGNLQANMSRQGVNTVQKGCCNACEKPI--VGQVITALGKTWHPEHFTCNHCSQELGTRNFF 387
            ...|.....:..||  |......|..|.:|:  ....:.|||:.:|...|||:.|:|:|..:.|:
Human   363 TQQLMQDMEHPQRQ--NVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFY 425

  Fly   388 ERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQF-GEEGFHERDGK 451
            ..:|.||||..|.:... :|..|...|.|:.:.|..|.:|...|.|..|.:.. |.....::..:
Human   426 SLEGAPYCEGCYTDTLE-KCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANR 489

  Fly   452 PYCRNDYFEMFAPKCNGCNRAIMEN-------YISALNSQWHPDCFVCRDCRQPF----QGGSFF 505
            |:|..||.:.:||:|:.|:..||..       .:.||:..:|..|:.|.||.:|.    .....|
Human   490 PHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCF 554

  Fly   506 DHEGLPYCETHYHAK 520
            ..:|...|...:.|:
Human   555 PLDGHVLCRKCHTAR 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	19/53 (36%)
		LIM2_Paxillin_like	407..458	CDD:188723	13/51 (25%)
		LIM3_Paxillin_like	466..518	CDD:188724	15/62 (24%)
		LIM4_Paxillin	525..576	CDD:188795
ZYX	NP_001010972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..351		48/247 (19%)
		PAT1	<201..>365	CDD:330585	38/197 (19%)
		LIM1_Zyxin	351..437	CDD:188735	27/87 (31%)
		LIM	444..503	CDD:295319	16/58 (28%)
		LIM3_Zyxin	504..570	CDD:188819	16/66 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910