DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Pdlim7

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001107560.1	Gene:	Pdlim7 / 67399	MGIID:	1914649	Length:	457	Species:	Mus musculus

Alignment Length:	474	Identity:	125/474 - (26%)
Similarity:	174/474 - (36%)	Gaps:	97/474 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GHDFN-----------GSSTTPGYA-----------NQGSLPR-------QAAG--ASTGLSELD 131
            |.|||           |.:...|.|           |.|||..       :|.|  .|.|||...
Mouse    21 GKDFNVPLSISRLTPGGKAAQAGVAVGDWVLNIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQ 85

  Fly   132 SLLQDLQKIDVP------VNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHK 190
            .:....||...|      ..::...|...|...:..   .|..||.|::........||:.|..:
Mouse    86 PVQSKPQKALTPPADPPRYTFAPSASLNKTARPFGA---PPPTDSTLRQNGQLLRQPVPDASKQR 147

  Fly   191 --------SPTPG----RHVTITVRETKTEKLTGPDGPVGTVEEQIVQQK----DSYTPNHAVPG 239
                    .|.||    |...|....|.||.:..||........|:.:.:    .|..|..:.||
Mouse   148 LMEDTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEFMKKSSQVPRTEAPAPASTIPQESWPG 212

  Fly   240 QQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQA 304
            ... .:.||:....:|...|.                .:....:|||.          .:.||.|
Mouse   213 PTT-PSPTSRPPWAVDPAFAE----------------RYAPDKTSTVL----------TRHSQPA 250

  Fly   305 HLTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHP 369
            ..|.....|:||:        :..|......|..|...|    |:.|.|.|.|:.:.|||..:||
Mouse   251 TPTPLQNRTSIVQ--------AAAGGGTGGGSNNGKTPV----CHQCHKIIRGRYLVALGHAYHP 303

  Fly   370 EHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCA 434
            |.|.|:.|.:.|....|||..|..:|...|...::|.||.|...|..:.:.||..|||...|.||
Mouse   304 EEFVCSQCGKVLEEGGFFEEKGAIFCPSCYDVRYAPNCAKCKKKITGEIMHALKMTWHVHCFTCA 368

  Fly   435 QCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAI--MENYISALNSQWHPDCFVCRDCRQ 497
            .|........|:..:|.|||..||.:||..||.||:..|  .:.::.||...||..||||..|:.
Mouse   369 ACKTPIRNRAFYMEEGAPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQI 433

  Fly   498 PFQGGSFFDHEGLPYCETH 516
            ..:|.:|:..:..|.|::|
Mouse   434 NLEGKTFYSKKDKPLCKSH 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	20/51 (39%)
		LIM2_Paxillin_like	407..458	CDD:188723	18/50 (36%)
		LIM3_Paxillin_like	466..518	CDD:188724	18/53 (34%)
		LIM4_Paxillin	525..576	CDD:188795
Pdlim7	NP_001107560.1	PDZ_signaling	5..79	CDD:238492	13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..166		16/86 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..226		7/41 (17%)
		LIM1_Enigma	282..333	CDD:188836	20/50 (40%)
		LIM2_Enigma	341..392	CDD:188840	18/50 (36%)
		LIM3_Enigma	400..454	CDD:188842	18/53 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810