Protein Alignment Pax and Lima1

DIOPT Version :9

• Sequence 1: NP_001033913.1
• Gene: Pax / 35215
• FlyBaseID: FBgn0041789
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001107017.1
• Gene: Lima1 / 65970
• MGIID: 1920992
• Length: 753
• Species: Mus musculus
• Alignment Length: 443
• Identity: 87/443 - (19%)
• Similarity: 142/443 - (32%)
• Gaps: 115/443 - (25%)

  Fly   151 SKYNTMNSYATVE-------------ERPSVDSLLKELDNA------HIYAVPNGSA---HKSPT 193
            |||......|.:|             .|.::..|.|:.:|.      |..::||.|:   |.:..
Mouse    39 SKYQKAAEEANMERKKNNPESLPQHFRRGTLSVLKKKWENPVAGAEFHTDSLPNSSSEGGHTADY 103

  Fly   194 PGRHVTIT----VRETKTEKLTGPDGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKE- 253
            |...||..    ||..: |:.|.|....|:..|.::|.:        .|..:....:.:|||:.
Mouse   104 PPAEVTDKPAPGVRADR-EEHTQPKPRFGSRPEAVIQSR--------YPRSENSHDFKAQATESQ 159

  Fly   254 -----LDDLMASLSDFKVSNGTNGIG-----------------NGSHPQQHSSTVQHQTVTDYAR 296
                 |.|........:.|..|...|                 .|.|.|..|...|.:
Mouse   160 KMENCLGDSRHEAEKPETSENTETSGKIEKYNVPLNRLKMMFEKGEHNQTKSLWTQSR------- 217

  Fly   297 PNKGSQQAHLTQTIEETTIVEDSRE---DQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQ 358
             |.|.::      :.|.....|..|   ..|.|...|.:.|.|::.:...:  ......|..:.:
Mouse   218 -NAGGRR------LSENNCSLDDWEIGAGHLSSSAFNSEKNESKRNLELPR--LSETSIKDRMAK 273

  Fly   359 VITALGKTWHPEHFTCNHCSQELGTRNFFERDGFP----YCEPDYHNLFSPRCAYCNGAILDKCV 419
            ...|:.|...|..:|....:.|..|..:.:::..|    .|  ..|...| :.:....:::...|
Mouse   274 YQAAVSKQSSPASYTNELKTSESKTHKWEQKENVPPGPEAC--SVHQEGS-KVSTTENSLVALSV 335

  Fly   420 TALDKTWHTEHFFCAQCGQQFGEEG---FHERDGKPYCRNDYFEMFAP-------------KCNG 468
            .|.|.|          |..|...|.   .|.:...|..|.......:|             .|..
Mouse   336 PAEDDT----------CNSQVKSEAQQPMHPKPLSPDARTSSLPESSPSKTAKKFQAPAKESCVE 390

  Fly   469 CNRAI--MENYISALNSQ-WHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYH 518
            |.:.:  ||..::  |.| :|..||.|..|......|::....|..||:.|::
Mouse   391 CQKTVYPMERLLA--NQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFN 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	9/55 (16%)
		LIM2_Paxillin_like	407..458	CDD:188723	10/53 (19%)
		LIM3_Paxillin_like	466..518	CDD:188724	16/54 (30%)
		LIM4_Paxillin	525..576	CDD:188795
Lima1	NP_001107017.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..66		2/19 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..186		24/112 (21%)
		Required for interaction with NPC1L1. /evidence=ECO:0000269|PubMed:29880681	164..166		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	276..326		10/52 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..379		8/47 (17%)
		LIM_Eplin_alpha_beta	388..440	CDD:188869	15/53 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	467..493
		Required for interaction with MYO5B. /evidence=ECO:0000269|PubMed:29880681	491..511
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..669
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..703

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910