DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Pdlim5

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_006233474.1	Gene:	Pdlim5 / 64353	RGDID:	621076	Length:	624	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	125/515 - (24%)
Similarity:	186/515 - (36%)	Gaps:	159/515 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QNSVPG----QPQQPQPQYGTVQ--------PKHQALQQQQFVDNTPGYGSLRGKAQPQVYQ--- 85
            ||..||    .|::| |:...|:        |.|....:::.:::|..:....|..|.:.::
  Rat   235 QNGNPGTVKIPPKRP-PRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILA 298

  Fly    86 -----EHYSVETRSPTAGHDFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKIDVPVN 145
                 ||.. |:.:..|    ..:::||..:.|.:.|..||
  Rat   299 QITGTEHLK-ESENDNA----KKANSTPEPSQQSASPLSAA------------------------ 334

  Fly   146 YSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKL 210
                                   :||                  :||...|.|...:|.....|
  Rat   335 -----------------------ESL------------------ESPGSNRPVVAGLRSAAAFK- 357

  Fly   211 TGPDGPVGTVEEQIVQQKDSYTPNHA---------VPGQQVHQAYTSQATKELDDLMASLSDFKV 266
                 |||:..   |:......||.|         |..|.....:.|:|.          |..::
  Rat   358 -----PVGSTS---VKSPSWQRPNQAGTSMRKCGDVRSQHTQICFGSKAP----------STGRI 404

  Fly   267 SNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNL 331
            ||..:..|.|: |.               :|..|..|..     ::.|:|:  |.:.:.:
  Rat   405 SNSASSSGTGA-PM---------------KPAVGPPQPS-----DQDTLVQ--RAEHIPA----- 441

  Fly   332 QANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCE 396
                   |..|..   |..|.:.|.|..:.||||:||||.|.|.||...:....|.|..|..|||
  Rat   442 -------GKRTPM---CAHCNQAIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCE 496

  Fly   397 PDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEM 461
            ..|...|:|.|..|...||.:.:.||.:|||...|.|..||:......||..||:|||..||:.:
  Rat   497 LCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYAL 561

  Fly   462 FAPKCNGCNRAIM--ENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHA 519
            |...|.||...|.  :.::.||.|.||..||||..|.:..:|.:||..:..|.|:.|.|:
  Rat   562 FGTICRGCEFPIEAGDMFLEALGSTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	22/51 (43%)
		LIM2_Paxillin_like	407..458	CDD:188723	20/50 (40%)
		LIM3_Paxillin_like	466..518	CDD:188724	20/53 (38%)
		LIM4_Paxillin	525..576	CDD:188795
Pdlim5	XP_006233474.1	PDZ_signaling	10..82	CDD:238492
		DUF4749	214..305	CDD:292558	13/70 (19%)
		LIM1_ENH	448..499	CDD:188837	22/50 (44%)
		LIM	507..558	CDD:295319	20/50 (40%)
		LIM	566..620	CDD:295319	20/53 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810