Protein Alignment Pax and PDLIM2

DIOPT Version :9

• Sequence 1: NP_001033913.1
• Gene: Pax / 35215
• FlyBaseID: FBgn0041789
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_067643.3
• Gene: PDLIM2 / 64236
• HGNCID: 13992
• Length: 602
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 99/501 - (19%)
• Similarity: 151/501 - (30%)
• Gaps: 154/501 - (30%)

  Fly     7 GKIDPGARQPYRTARSKGILPGYALL-ADLQNSVPGQPQQP---------QPQYGTVQPKHQALQ 61
            |:..||.|...|.: ::..|||..|| |.|....||..:.|         .|....:.|....|.
Human   144 GERQPGERAHLRLS-ARPALPGAGLLSAPLSARNPGLVRGPAPWSLASAGAPPRAALSPAGALLL 207

  Fly    62 Q----QQFVDNTPGYGSLRGKAQPQVYQE----------------HYSVETRSP-------TAGH 99
            |    :.....:.| ||..|:|.|..:..                ..:|:...|       |.|.
Human   208 QPPARRVLCPRSEG-GSRTGRAGPSGWAPPRGARSAESTDRLKGMALTVDVAGPAPWGFRITGGR 271

  Fly   100 DFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKIDVPVNYSTPVSKYNTMNSYATVEE 164
            ||:........|.:|    :|..|            ||:..|:.|..:.. |....:::.|..:.
Human   272 DFHTPIMVTKVAERG----KAKDA------------DLRPGDIIVAINGE-SAEGMLHAEAQSKI 319

  Fly   165 RPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKL-TGPDGPVGTVEEQIVQQK 228
            |.|...|..:||.:           ::.:||:    |..::..|.| |...|.|.|..|.....:
Human   320 RQSPSPLRLQLDRS-----------QATSPGQ----TNGDSSLEVLATRFQGSVRTYTESQSSLR 369

  Fly   229 DSY-TPNHAVP--GQQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQT 290
            .|| :|....|  |.......:|.:......:..|......|.|.......|:.
Human   370 SSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYS----------- 423

  Fly   291 VTDYARPNKGSQQAHLTQTIEETTIV------EDSREDQLDSMLGN------------LQAN--- 334
                .||  ||:||.|.:..:...:|      ..|....:||..|:            ||.|
Human   424 ----GRP--GSRQAGLGRAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREG 482

  Fly   335 -----------MSRQGVNTVQKG-----------------------------CCNACEKPIVGQV 359
                       :.::.:...::|                             .|..|...|..|.
Human   483 RAAPRQSSSFRLLQEALEAEERGGTPAFLPSSLSPQSSLPASRALATPPKLHTCEKCSTSIANQA 547

  Fly   360 ITAL-GKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFS 404
            :... |:..||..:||..|...|..|..|......|||......:|
Human   548 VRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGDELYCEKHARQRYS 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	16/52 (31%)
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
PDLIM2	NP_067643.3	PDZ_signaling	259..330	CDD:238492	18/87 (21%)
		DUF4749	<462..505	CDD:292558	4/42 (10%)
		LIM_Mystique	536..588	CDD:188833	16/51 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900