DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax and wtip

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001116750.2	Gene:	wtip / 566046	ZFINID:	ZDB-GENE-050419-261	Length:	648	Species:	Danio rerio

Alignment Length:	627	Identity:	130/627 - (20%)
Similarity:	210/627 - (33%)	Gaps:	199/627 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 NGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKIDVPVNYSTPVSK--YNTMNSYATVEE 164
            ||||:|||.....:.|.::...:              :..||:::.:|..:  |...:.|.|..|
Zfish    44 NGSSSTPGNKVYSAAPVRSVNGN--------------RASVPLDFCSPQREAVYPDPDVYCTKSE 94

  Fly   165 -----RPSVDSLLKELDNAHI--YAVPNGSAHKSPTPGRHVTITVRETKTEKLTGPDG------P 216
                 .......|:...:|.:  :....|.|:.....|:.|.::...:.:..::.|||      |
Zfish    95 VALPCYSGASDRLRRYTHAEVQGHRYSTGCAYDGLVLGKQVAVSGARSNSLCMSSPDGRYTATSP 159

  Fly   217 VGTVEEQIVQQKDS--YTPNHAV---------PGQ-------QVHQAYTSQA--TKELDDLMASL 261
            ..::......|..|  .:|..::         |||       ....:|.|.|  |.:......||
Zfish   160 RSSLASSHSSQDQSKHTSPRSSISSPRSSLVSPGQGEGTSVISPRSSYASTASDTSKHSSPRTSL 224

  Fly   262 SDFKV-----SNGTNGIGNGSHPQQH-----SSTVQHQTVTD----------------------- 293
            :.:..     ||.|:||..| :.|:|     |:|....:.:|
Zfish   225 NSYDCGSKPSSNRTSGISMG-YDQRHISPRSSTTSPRSSYSDSRFTPAGGHDPESAAVHGIPMAS 288

  Fly   294 -----------------------------YARPNKGSQQAH-------LTQTIEETTIVEDSRED 322
                                         .:|.::||..|:       |...:.|..:::|..|
Zfish   289 PRSSICSQPAVAANCVVSPRSSISSHSSRSSRSSRGSMSAYPELQLPMLGPGLPEDALLQDFTE- 352

  Fly   323 QLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFF 387
              .:.|.|          |.|........|:|........:|         .|:|....|.:.|.
Zfish   353 --PNGLHN----------NRVHLQTFPVLEEPQQQNSEVNIG---------FNYCKAGAGGQRFK 396

  Fly   388 -------ERDGFP--------------------YCEPDYHNLFSPRCAYCNGAI--LDKCVTALD 423
                   .||..|                    :.:.:|..:    |..|...:  ..:...|:.
Zfish   397 LPYQVTPSRDSGPSQAERRLEALTLELEKELEIHMKKEYFGI----CVKCGKGVYGASQACQAMG 457

  Fly   424 KTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDY----FEMFAPKCNGCNRAIMENYISALNSQ 484
            ..:||..|.|..||::...:.|:..:||.||..|:    |:..|.||..|...|||..:.||...
Zfish   458 NLYHTNCFTCCSCGRRLRGKAFYNVNGKVYCEEDFLYSGFQQTAEKCFVCGHLIMEMILQALGRS 522

  Fly   485 WHPDCFVCRDCRQPFQGGSF-FDHEGLPYCETHYHAKRGSLCAGCSKPI--------TGRCITAM 540
            :||.||.|..|::...|..| .|.|...||...||......||.|::||        |.| :.:|
Zfish   523 YHPGCFRCVICKEGLDGVPFTVDVENNIYCVKDYHTVFAPKCASCNQPILPAQGSEETIR-VVSM 586

  Fly   541 FKKFHPEHFVCAFCLKQLNKGTFKEQKDKPY-------CHTC 575
            .|.:|.:.:.|..|..|||    .|:..:.|       ||.|
Zfish   587 DKDYHVDCYHCEDCGLQLN----DEEGHRCYPLEGHLLCHRC 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	10/78 (13%)
		LIM2_Paxillin_like	407..458	CDD:188723	14/52 (27%)
		LIM3_Paxillin_like	466..518	CDD:188724	19/52 (37%)
		LIM4_Paxillin	525..576	CDD:188795	20/66 (30%)
wtip	NP_001116750.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..56		7/11 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..291		27/149 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..327		3/20 (15%)
		LIM1_Ajuba_like	439..492	CDD:188738	14/52 (27%)
		LIM2_Ajuba_like	504..556	CDD:188741	19/51 (37%)
		LIM3_Ajuba_like	564..625	CDD:188822	20/66 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910