DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and pdlim3b

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_005157291.1	Gene:	pdlim3b / 561865	ZFINID:	ZDB-GENE-060130-104	Length:	332	Species:	Danio rerio

Alignment Length:	424	Identity:	79/424 - (18%)
Similarity:	140/424 - (33%)	Gaps:	158/424 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KIDPGARQPYRTARSKGILPGYALL------------ADLQNSVPGQPQQ-----PQPQYGTVQP 55
            ::.||::     |....:.||..:|            |:.||::.....|     .:|:.....|
Zfish    31 RVTPGSK-----ASRVNLCPGDIILSIQGVSTDGMTHAEAQNNIKDSTNQLFLKIERPETKIWSP 90

  Fly    56 KHQALQQQQFVDNTPGYGSLRGKAQPQVYQEH-YSVETRSPTAGHDFNGSSTTPGYANQGSLPRQ 119
              |.:::.:.   .|...:|..:.|...|.|| ::|..:..|:....:.|::   ....|::.:.
Zfish    91 --QVIEEGKV---NPFKINLEAEKQDIDYFEHKFNVRPKPFTSASQRSDSTS---QTLMGNVAQM 147

  Fly   120 AAGASTGLSELDSLLQDLQKIDVPVNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVP 184
            |...||..|               |.|::||:.|             |.|::...|..|.:..|.
Zfish   148 AGTPSTAHS---------------VQYNSPVALY-------------SADNVSNTLQQAQMSTVV 184

  Fly   185 NGSAHKSPTPGRHVTITVRETKTEKLTGPDGPVGTVEEQIVQQ--KDSYTPNHAVPGQQVHQAYT 247
            ..::..|.                       |:.::|:..|.:  :|:        .:|.|:...
Zfish   185 RQASPSSK-----------------------PLTSIEDSHVYRMLQDA--------NEQPHEPRQ 218

  Fly   248 SQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEE 312
            |.:.|.|.|.:.|              :|:.|.          ||...:......|| .|.::::
Zfish   219 SGSFKALQDYVES--------------DGTRPM----------VTRSVKAPVTKPQA-ATSSLQK 258

  Fly   313 TTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHC 377
            ..:                                |:.|...|||.|:.|..|..||..|.|:.|
Zfish   259 LPL--------------------------------CDKCGTGIVGTVVKARDKYRHPACFVCSDC 291

  Fly   378 SQELGTRNFFERDGFPYCE---------PDYHNL 402
            ...|..:.:|..||..|||         |:.|:|
Zfish   292 GMNLKQKGYFFVDGQMYCEAHARMRMTPPEGHDL 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	21/60 (35%)
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
pdlim3b	XP_005157291.1	PDZ_signaling	2..81	CDD:238492	10/54 (19%)
		DUF4749	156..232	CDD:292558	23/148 (16%)
		LIM_ALP	262..314	CDD:188834	20/51 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810