DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and lpxn

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_689239.4	Gene:	lpxn / 560743	ZFINID:	ZDB-GENE-081105-159	Length:	405	Species:	Danio rerio

Alignment Length:	431	Identity:	187/431 - (43%)
Similarity:	249/431 - (57%)	Gaps:	48/431 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 VDSLLKELDNAHIYAVPNGSAHKSP-------TPGRHVTITVRETKTEKLTGPDGPVGTVEEQIV 225
            :|.||::|       ..|.|....|       |...:.|..:::|::..|..  ||
Zfish     4 LDMLLEQL-------AQNSSEASDPPVLLPAKTLKNNNTTVLQQTESSSLIA--GP--------- 50

  Fly   226 QQKDSYTPNHAVPGQQVHQAYTS--QATKELDDLMASL--SDFKVSNGTNGIGNGSHPQQHSSTV 286
              :.::...::||...|..:..|  .||:|||.||..|  .|.:||...   .:.:.|.....::
Zfish    51 --RQTFDNPYSVPTAPVEASLMSPRTATRELDSLMNDLLGLDLEVSEPA---PSSNPPPLARKSI 110

  Fly   287 QHQTVTDYARPNKGSQQAH-------LTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQ 344
            :.:|..:......|.|:..       |::...:..       |.:|.:||:|.::|.:.||.|..
Zfish   111 KAKTTEETGESGSGRQEGDRKPQHPPLSEKFSKGV-------DAIDDLLGSLSSDMEKMGVRTAA 168

  Fly   345 KGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAY 409
            ||.|.:|.|.|.|::|||||:.||||||.|:.|.:||||..||||||.||||.||..||||||||
Zfish   169 KGHCASCGKCIAGKMITALGQVWHPEHFVCSACREELGTCGFFERDGKPYCEKDYQKLFSPRCAY 233

  Fly   410 CNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIM 474
            |.|.|....:||:|:|||.|||||..||..||.||:.||||||||..|::.:|||||:||...:.
Zfish   234 CKGPITQNILTAMDQTWHPEHFFCCHCGDLFGPEGYLERDGKPYCSRDFYCLFAPKCSGCGEPVK 298

  Fly   475 ENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITA 539
            |||:||.|..||||||||.||.:||..|.|.:..|.|.|..|||:::|:||..|.|||.||||.|
Zfish   299 ENYLSAANGTWHPDCFVCSDCLKPFTDGCFLELNGRPLCSLHYHSRQGTLCGTCGKPIAGRCIAA 363

  Fly   540 MFKKFHPEHFVCAFCLKQLNKGTFKEQKDKPYCHTCFDKIF 580
            :.:|||||||||||||:||::|.||||..||||..|..|:|
Zfish   364 LDRKFHPEHFVCAFCLRQLSQGVFKEQAGKPYCSVCHAKLF 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	33/51 (65%)
		LIM2_Paxillin_like	407..458	CDD:188723	31/50 (62%)
		LIM3_Paxillin_like	466..518	CDD:188724	27/51 (53%)
		LIM4_Paxillin	525..576	CDD:188795	34/50 (68%)
lpxn	XP_689239.4	LIM1_Paxillin_like	172..224	CDD:259830	33/51 (65%)
		LIM2_Leupaxin	231..282	CDD:188792	31/50 (62%)
		LIM3_Leupaxin	290..342	CDD:188794	27/51 (53%)
		LIM4_Leupaxin	349..400	CDD:188796	34/50 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583860
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104097
Panther	1	1.100	-	-	O	PTHR24216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.710