DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax and fhl3b

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001093448.1	Gene:	fhl3b / 555053	ZFINID:	ZDB-GENE-030131-8356	Length:	290	Species:	Danio rerio

Alignment Length:	347	Identity:	87/347 - (25%)
Similarity:	122/347 - (35%)	Gaps:	99/347 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 ETKTEKLTGPDGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKELDDLMASLSDFKVSN 268
            |:..|.|.|         ::.:|..|.   .|.||......|.|....|||
Zfish     8 ESCKESLYG---------QKYIQVDDK---PHCVPCYDRLHANTCHECKEL-------------- 46

  Fly   269 GTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQA 333
                |.:.|....|.....|:.....:|.::              ::.::|...|.|:::
Zfish    47 ----IEHNSRELYHEDRHYHEQCFRCSRCSR--------------SLAKESFTCQEDALV----- 88

  Fly   334 NMSRQGVNTVQKGCCNACEKPIVGQVITALGKT--------------WHPEHFTCNHCSQELGTR 384
                          ||.|..........|.|||              ||.|.|.|..|.|.:|.:
Zfish    89 --------------CNNCYCNEFSSNCVACGKTVMPGSKRLEYEDCVWHEECFVCCGCEQPIGAQ 139

  Fly   385 NFF-ERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHER 448
            :|. ::|.: ||.|.|...|:||||:|...::...||..|:.||.|.|.|..|..|...:.|..:
Zfish   140 SFIPDKDEY-YCVPCYEGRFAPRCAHCKQTLVQGGVTYRDEPWHKECFLCTGCKVQLAGQPFTTQ 203

  Fly   449 DGKPYCRNDYFEMFAPKCNGCNRAIM----ENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEG 509
            ...|||...:..::|.||..|.:.|.    ..|:|....|||..||.|..|.....|..||.|
Zfish   204 GEDPYCVKCFSNLYAQKCAACEKPITGFGEGKYVSFEERQWHKPCFKCSVCSLSLVGAGFFPH-- 266

  Fly   510 LPYCETHYHAKRGS--LCAGCS 529
                        ||  ||.||:
Zfish   267 ------------GSMILCKGCN 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	20/66 (30%)
		LIM2_Paxillin_like	407..458	CDD:188723	17/50 (34%)
		LIM3_Paxillin_like	466..518	CDD:188724	16/55 (29%)
		LIM4_Paxillin	525..576	CDD:188795	3/5 (60%)
fhl3b	NP_001093448.1	LIM	<5..33	CDD:295319	9/36 (25%)
		LIM1_FHL3	36..94	CDD:188807	16/108 (15%)
		LIM2_FHL3	98..155	CDD:188811	17/57 (30%)
		LIM3_FHL	162..213	CDD:188732	17/50 (34%)
		LIM4_FHL3	221..276	CDD:188818	21/68 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910