DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax and Tes

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001034433.1	Gene:	Tes / 500040	RGDID:	1566346	Length:	419	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	85/394 - (21%)
Similarity:	147/394 - (37%)	Gaps:	69/394 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SLLQDLQKIDVPVN------YSTPV-SKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAH 189
            :|:..|:...:|:.      .:.|| :|.|...:..|.|..|.|.:  :.|...::..:|.   .
  Rat    74 TLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQN--QALARQYMQMLPK---E 133

  Fly   190 KSPTPGRHVTITVRETKTEKLTGPDGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKEL 254
            |.|                 :.|.:| ....::|:.:|    .|.|.....:.|: .:.:..||:
  Rat   134 KQP-----------------VAGSEG-AQYRKKQLAKQ----LPAHDQDPSKCHE-LSPKEVKEM 175

  Fly   255 DDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDS 319
            :..:.     |..:...|:|:...|.:               .|....:.|.......|.....|
  Rat   176 EQFVK-----KYKSEALGVGDVKLPSE---------------MNAQGDKVHNPAGDRNTPAAVGS 220

  Fly   320 REDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTR 384
            ::...::..........:   ||:::|      .|.:........|.|||..|.|:.|.:.|...
  Rat   221 KDKSAEAKKTQYSCYCCK---NTMREG------DPAIYAERAGYDKLWHPACFICSTCGELLVDM 276

  Fly   385 NFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVT-ALDKTWHTEHFFCAQCGQQFGEEGFHER 448
            .:|.::|..||...|.:...||||.|:..|.....| |.::.||.:||.|..|......:.:...
  Rat   277 IYFWKNGKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDNILAGKIYVMV 341

  Fly   449 DGKPYCRNDYFEMFAPKCNGCNRAIMENY--ISALNSQWH--PDCFVCRDCRQPFQGGSFFDHEG 509
            ..||.|:..|.:..|..|.||:.||....  ::..|..||  .:||:|..|.:...|..|...||
  Rat   342 RDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEG 406

  Fly   510 LPYC 513
            :.:|
  Rat   407 MVFC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	13/51 (25%)
		LIM2_Paxillin_like	407..458	CDD:188723	15/51 (29%)
		LIM3_Paxillin_like	466..518	CDD:188724	17/52 (33%)
		LIM4_Paxillin	525..576	CDD:188795
Tes	NP_001034433.1	PET_testin	109..196	CDD:193604	20/119 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	133..164		8/52 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222		4/22 (18%)
		LIM1_Testin	234..291	CDD:188797	16/65 (25%)
		LIM2_Testin	297..352	CDD:188800	17/54 (31%)
		LIM3_Testin	359..417	CDD:188803	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910