DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and NRAP

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001248392.1	Gene:	NRAP / 4892	HGNCID:	7988	Length:	1731	Species:	Homo sapiens

Alignment Length:	119	Identity:	27/119 - (22%)
Similarity:	40/119 - (33%)	Gaps:	33/119 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 CNGCNRAIM-ENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCS 529
            |:.|...:. ...||.::..||..||.|..|:......:|..|:..|||..| :.|..:..:...
Human     6 CSRCGYGVYPAEKISCIDQIWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAH-NPKNNTFTSVYH 69

  Fly   530 KPITGRCITAMFKKFHPEHFVCAFCLKQLNKGTFKE-------QKDKPYCHTCF 576
            .|:                        .||..||.|       |:|...|.:.|
Human    70 TPL------------------------NLNVRTFPEAISGIHDQEDGEQCKSVF 99

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724	16/52 (31%)
		LIM4_Paxillin	525..576	CDD:188795	9/57 (16%)
NRAP	NP_001248392.1	LIM_N_RAP	6..58	CDD:188830	16/52 (31%)
		Nebulin 1. /evidence=ECO:0000255	63..97		9/57 (16%)
		Nebulin 2. /evidence=ECO:0000255	156..166
		Nebulin 3. /evidence=ECO:0000255	175..202
		Nebulin 4. /evidence=ECO:0000255	203..237
		NEBU	204..234	CDD:128523
		Nebulin 5. /evidence=ECO:0000255	246..273
		Nebulin 6. /evidence=ECO:0000255	298..307
		Nebulin 7. /evidence=ECO:0000255	316..343
		Nebulin	316..342	CDD:279252
		Nebulin 8. /evidence=ECO:0000255	348..382
		Nebulin 9. /evidence=ECO:0000255	389..417
		Nebulin 10. /evidence=ECO:0000255	419..453
		Nebulin 11. /evidence=ECO:0000255	487..521
		NEBU	488..518	CDD:128523
		Nebulin 12. /evidence=ECO:0000255	522..556
		Nebulin	530..555	CDD:279252
		Nebulin 13. /evidence=ECO:0000255	558..592
		Nebulin	565..591	CDD:279252
		Nebulin 14. /evidence=ECO:0000255	602..626
		Nebulin 15. /evidence=ECO:0000255	627..661
		NEBU	628..658	CDD:128523
		Nebulin 16. /evidence=ECO:0000255	662..692
		Nebulin 17. /evidence=ECO:0000255	702..724
		Nebulin 18. /evidence=ECO:0000255	726..760
		NEBU	727..757	CDD:128523
		Nebulin 19. /evidence=ECO:0000255	761..795
		NEBU	762..792	CDD:128523
		Nebulin 20. /evidence=ECO:0000255	797..831
		Nebulin 21. /evidence=ECO:0000255	844..869
		Nebulin 22. /evidence=ECO:0000255	870..896
		Nebulin 23. /evidence=ECO:0000255	901..935
		Nebulin 24. /evidence=ECO:0000255	945..963
		Nebulin 25. /evidence=ECO:0000255	969..1003
		NEBU	970..1000	CDD:128523
		Nebulin 26. /evidence=ECO:0000255	1004..1038
		NEBU	1005..1035	CDD:128523
		Nebulin 27. /evidence=ECO:0000255	1040..1074
		Nebulin	1049..1073	CDD:279252
		Nebulin 28. /evidence=ECO:0000255	1078..1112
		Nebulin 29. /evidence=ECO:0000255	1113..1139
		Nebulin 30. /evidence=ECO:0000255	1144..1178
		Nebulin 31. /evidence=ECO:0000255	1183..1206
		Nebulin 32. /evidence=ECO:0000255	1212..1246
		Nebulin 33. /evidence=ECO:0000255	1247..1281
		Nebulin 34. /evidence=ECO:0000255	1283..1317
		Nebulin 35. /evidence=ECO:0000255	1321..1355
		Nebulin 36. /evidence=ECO:0000255	1356..1390
		NEBU	1357..1387	CDD:128523
		Nebulin 37. /evidence=ECO:0000255	1391..1421
		Nebulin 38. /evidence=ECO:0000255	1429..1449
		Nebulin 39. /evidence=ECO:0000255	1455..1481
		Nebulin 40. /evidence=ECO:0000255	1490..1524
		Nebulin 41. /evidence=ECO:0000255	1526..1560
		Nebulin 42. /evidence=ECO:0000255	1564..1598
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1595..1620
		Nebulin 43. /evidence=ECO:0000255	1599..1626
		Nebulin 44. /evidence=ECO:0000255	1640..1664
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910