DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and PRICKLE3

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_006141.2	Gene:	PRICKLE3 / 4007	HGNCID:	6645	Length:	615	Species:	Homo sapiens

Alignment Length:	359	Identity:	91/359 - (25%)
Similarity:	133/359 - (37%)	Gaps:	71/359 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 HAVPGQQVHQAYTSQATKELDDLMASL-SDFK---VSNGTNGIGN--------GSHPQ---QHSS 284
            ||||             .:|:.:|..| |||:   :|:..:|..:        |..|:   |..|
Human    59 HAVP-------------VDLERIMCRLISDFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFS 110

  Fly   285 TVQHQTVTDYARPNKGSQQAHLTQTIEE-----------TTIVEDSREDQLDSMLGNLQANMSRQ 338
            .:....| .|.  |...::..:.|.:.:           |.:.|:.:::.........:.|:.|.
Human   111 CLPEDKV-PYV--NSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRG 172

  Fly   339 GVN----TVQKGCCNACEKPIVGQVI------TALGKTWHPEHFTCNHCSQELGTRNFFERDGFP 393
            .|.    |:....|..|.|.|.|..|      ..||..|||:.|.|..|.:.|....:|...|..
Human   173 IVRIFPVTITGAICEECGKQIGGGDIAVFASRAGLGACWHPQCFVCTTCQELLVDLIYFYHVGKV 237

  Fly   394 YCEPDYHNLFSPRCAYCNGAILD-KCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRND 457
            ||...:.....|||..|:..|.. :|..|..:.||.:||.|.:|....|.:.:..|..:|:|...
Human   238 YCGRHHAECLRPRCQACDEIIFSPECTEAEGRHWHMDHFCCFECEASLGGQRYVMRQSRPHCCAC 302

  Fly   458 YFEMFAPKCNGCNRAI-MENYISALNSQ-WHPD--CFVCRDCRQPFQGGSFFDHEGLPYCE---- 514
            |....|..|:||...| ::....|...| ||..  ||.|..|.:...|..|....||.:|.
Human   303 YEARHAEYCDGCGEHIGLDQGQMAYEGQHWHASDRCFCCSRCGRALLGRPFLPRRGLIFCSRACS 367

  Fly   515 -----THYHAKRGSLCAGCSKPITG--RCITAMF 541
                 |.....|.|..||   |:|.  ...||.|
Human   368 LGSEPTAPGPSRRSWSAG---PVTAPLAASTASF 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	19/57 (33%)
		LIM2_Paxillin_like	407..458	CDD:188723	15/51 (29%)
		LIM3_Paxillin_like	466..518	CDD:188724	18/64 (28%)
		LIM4_Paxillin	525..576	CDD:188795	7/19 (37%)
PRICKLE3	NP_006141.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PET_Prickle	82..178	CDD:193602	15/98 (15%)
		LIM1_Prickle	186..244	CDD:188799	19/57 (33%)
		LIM2_Prickle	249..304	CDD:188802	17/54 (31%)
		LIM3_Prickle	309..367	CDD:188804	17/57 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..567		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..615
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910