DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and pdlim7

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_957134.1	Gene:	pdlim7 / 393813	ZFINID:	ZDB-GENE-040426-2092	Length:	419	Species:	Danio rerio

Alignment Length:	468	Identity:	128/468 - (27%)
Similarity:	182/468 - (38%)	Gaps:	96/468 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 YSVETRSPT-------AGHDFNG----SSTTPGYANQGSLPRQAAGASTGLSE-LDSLLQDLQKI 140
            |.|....|.       .|.|||.    |..|||        .:||.|..|:.: :.|:      .
Zfish     4 YCVTLNGPAPWGFRLQGGKDFNTPLTVSRLTPG--------GKAAQAGVGVGDWVVSI------F 54

  Fly   141 DVPVNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNA-HIYAVPNGSAHK------------SP 192
            |......|.|...|.:        |.:.|||...|..| |    |.|...|            |.
Zfish    55 DANAEEMTHVEAQNKI--------RAATDSLKLTLSRAFH----PAGGEQKDSLTSSSSQPKYSF 107

  Fly   193 TPGRHVTITVRETKTEKLTGPDGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKELD-- 255
            .|...:....|.......:|..|||  ::......|.:.:..|  .|..|.....:..:|..|
Zfish   108 APSTAINKMARPFSASPGSGSAGPV--IKPVSYALKPALSSPH--NGHGVAPCPVTVKSKPADKH 168

  Fly   256 DLMASLSDFKVSNG---------TNGIGNGSHPQQHSSTV-QHQTVTDYARPNKGSQQAHLTQTI 310
            |.:.:.:...||:|         ..|..:..||.:.|:.| ||                  ||.:
Zfish   169 DAVQAPAKAPVSSGPACRPPWVTDPGFADRYHPDKSSTVVTQH------------------TQPL 215

  Fly   311 EETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCN 375
            :.|.:...|         ..|||.......::.....|.||.|.|.|:.:.|||::||||.|.|.
Zfish   216 QPTPMQNRS---------SILQAAQQSPAHSSTATPLCAACSKIIRGRYVVALGRSWHPEEFMCC 271

  Fly   376 HCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQF 440
            .|.:.|....|||..|..||...|.|.:||.||.|...|..:.:.||..|:|.:.|.||.|....
Zfish   272 QCKRLLDEGGFFEEKGSIYCSKCYDNRYSPNCAKCKKIITGEIMHALKMTYHVQCFLCAACKLPI 336

  Fly   441 GEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAI--MENYISALNSQWHPDCFVCRDCRQPFQGGS 503
            ..:.|:..:|:|||..||.:||..||:||:..|  .:.::.||...||..||||..|:...:|.:
Zfish   337 RNQAFYMEEGEPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGYSWHDTCFVCAICQINLEGKT 401

  Fly   504 FFDHEGLPYCETH 516
            |:..:..|.|::|
Zfish   402 FYSKKDKPLCKSH 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	23/51 (45%)
		LIM2_Paxillin_like	407..458	CDD:188723	17/50 (34%)
		LIM3_Paxillin_like	466..518	CDD:188724	18/53 (34%)
		LIM4_Paxillin	525..576	CDD:188795
pdlim7	NP_957134.1	PDZ_signaling	3..81	CDD:238492	24/98 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..232		17/84 (20%)
		LIM1_Enigma	244..295	CDD:188836	23/50 (46%)
		LIM2_Enigma	303..354	CDD:188840	17/50 (34%)
		LIM3_Enigma	362..416	CDD:188842	18/53 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910