DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Zasp52

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	124/518 - (23%)
Similarity:	188/518 - (36%)	Gaps:	132/518 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PYRTARSKGILPGYALLADLQNSVPGQPQQ---PQPQYGTVQPKHQALQQQQFVDNTPGYGSLRG 77
            |.:.|.::.|:||||       :||...:.   |.|  |.:|.:.|..|:..|    .||.:...
  Fly  1790 PLKPAPAESIVPGYA-------TVPAATKMLTAPPP--GFLQQQQQQQQRSAF----SGYQATTS 1841

  Fly    78 KAQPQVYQEHYSVETRSPTAGHDFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQDLQKIDV 142
            ..|    |..::..:::.|:....:.:|               |.||..::.....|.....|..
  Fly  1842 SVQ----QSSFASSSKATTSSLSSSSAS---------------ASASASVARSSQSLTQASAITT 1887

  Fly   143 PVNYSTPVSKYNTMNSYAT---VEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRE 204
            ..| :...:.|.:.|...|   :..|||:.|:          ..|..::..:|.|....|
  Fly  1888 TTN-NQATTAYRSSNGSITKPNLASRPSIASI----------TAPGSASAPAPVPSAAPT----- 1936

  Fly   205 TKTEKLTGP-DGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKELDDLMASLSDFKVSN 268
                |.|.| ..|:                   ||...:..|..:.|..........|||..:::
  Fly  1937 ----KATAPFKAPI-------------------VPKSVIANAVNAAAPPAPAVFPPDLSDLNLNS 1978

  Fly   269 GTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQA 333
            ..:.                       .|..|.:.|                     ...|...|
  Fly  1979 NVDN-----------------------SPGAGGKSA---------------------GAFGATSA 1999

  Fly   334 NMSRQGVNTVQKG------CCNACEKPIVGQVITALGKTWHPEHFTC--NHCSQELGTRNFFERD 390
            ....:|:.....|      .||:|...|.|..|||||:.|.|:||.|  .:|.:.|....|.|..
  Fly  2000 PKRGRGILNKAAGPGVRIPLCNSCNVQIRGPFITALGRIWCPDHFICVNGNCRRPLQDIGFVEEK 2064

  Fly   391 GFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCR 455
            |..|||..:....:|.|:.|.|.|...|:.|:.|.:|.|.|.|.|||:.||...|...||..||.
  Fly  2065 GDLYCEYCFEKYLAPTCSKCAGKIKGDCLNAIGKHFHPECFTCGQCGKIFGNRPFFLEDGNAYCE 2129

  Fly   456 NDYFEMFAPKCNGCNRAIM--ENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETH 516
            .|:.|:|..||..|...:.  :.::.|||..:|..||.|..|:|..:|.||::..|.|:|:.|
  Fly  2130 ADWNELFTTKCFACGFPVEAGDRWVEALNHNYHSQCFNCTFCKQNLEGQSFYNKGGRPFCKNH 2192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	23/53 (43%)
		LIM2_Paxillin_like	407..458	CDD:188723	21/50 (42%)
		LIM3_Paxillin_like	466..518	CDD:188724	18/53 (34%)
		LIM4_Paxillin	525..576	CDD:188795
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492
		DUF4749	150..>217	CDD:292558
		LIM_ALP_like	282..333	CDD:188746
		LIM1_Enigma_like_1	2020..2073	CDD:188839	23/52 (44%)
		LIM	2081..2132	CDD:259829	21/50 (42%)
		LIM3_Enigma_like_1	2140..2193	CDD:188845	18/53 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I3371
eggNOG	1	0.900	-	-		E1_KOG1703
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	1	1.000	-	-		otm47179
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.810