DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pax and Pxn

DIOPT Version :9

Sequence 1:NP_001033913.1 Gene:Pax / 35215 FlyBaseID:FBgn0041789 Length:581 Species:Drosophila melanogaster
Sequence 2:XP_038945530.1 Gene:Pxn / 360820 RGDID:1305759 Length:1125 Species:Rattus norvegicus


Alignment Length:687 Identity:275/687 - (40%)
Similarity:348/687 - (50%) Gaps:132/687 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PGARQPYRT--ARSKGILPGYALLADLQNSVPGQPQ-----QPQPQYGT-------VQPKHQALQ 61
            |....||.|  ..|:|.:..:..|.:........||     :|:..:|.       ::|...|:.
  Rat   453 PPCHTPYPTGSTASQGPVATHVCLEETAGPTGRWPQALTASKPEIPHGVTYSFQEGIEPPAVAVD 517

  Fly    62 QQQFVDNTPGYGSLRGKAQPQVYQEHYSVETRSPTAGH--------DFNGSSTTPGYA------- 111
            :|..:.:|.......| .|.:|..|...:.:..|..||        .:.|....|..|       
  Rat   518 RQAVLPDTWALTQECG-LQERVQSEPGGLGSSCPALGHKEQLGGKRPWKGGLGGPTEALENPGKP 581

  Fly   112 ------------NQGSLPRQAAGASTGLSELDSLLQDLQKIDVPVNYSTPVSKYNTMN------- 157
                        .|..|.|..|..:...||..|....::.:   :..|......:.|:       
  Rat   582 EGSMEAALEPRKEQPELSRAMALGTPSTSERISTSGQIRSV---IRRSRETGHVHPMSREPSPRR 643

  Fly   158 --SYATVEERPSVDSLLKELD---NAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKLTGPDG-- 215
              ..||:...||.:.|:.||.   ...:.|.....|.........|.|||:         |.|  
  Rat   644 RLDPATLSRNPSQEQLIAELQGRLGIQLAAEEEAGASAQDWLTEGVVITVQ---------PRGRQ 699

  Fly   216 PVGTVEEQIVQQKDS----------YTPNHAVPGQQVHQAYTSQATKELDDLMASLS---DFKVS 267
            ..|.:.|::|...||          .:|....|..|.|.. ||.::..|...:.:.|   ....|
  Rat   700 AGGQLVEKVVYPPDSPIPLRRTTSVVSPPPPAPLLQNHPD-TSASSSPLQPSLPTPSCPGPLAGS 763

  Fly   268 NGTNGIGN-GSHPQQHS-------STVQHQTVTDYARPNKGSQQAH--LTQTIEETTIVE----- 317
            :.::|:.. |..||:..       ::|.| ||.............|  ..|.:|:...||     
  Rat   764 SASSGVQTAGEKPQEEGGRGPPGLTSVPH-TVRSVGCQTNEDPLFHPMQMQGLEQRVDVERQWAA 827

  Fly   318 ----DSRE------------------------------DQLDSMLGNLQANMSRQGVNTVQKGCC 348
                .||:                              .|||||||:||:::::.||.||.||.|
  Rat   828 GWPPSSRQSSPEGQDEGGFMAQGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVC 892

  Fly   349 NACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGA 413
            .||:|||.|||:||:|||||||||.|.||.:|:|:||||||||.||||.|||:||||||.||||.
  Rat   893 GACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGP 957

  Fly   414 ILDKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIMENYI 478
            ||||.|||||:|||.|||||||||..||.|||||:|||.|||.|||:||||||.||.|||:||||
  Rat   958 ILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYI 1022

  Fly   479 SALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKK 543
            ||||:.|||:|||||:|..||..||||:|:|.||||.|||.:|||||:||.|||||||||||.||
  Rat  1023 SALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKK 1087

  Fly   544 FHPEHFVCAFCLKQLNKGTFKEQKDKPYCHTCFDKIF 580
            |||||||||||||||||||||||.|||||.:||.|:|
  Rat  1088 FHPEHFVCAFCLKQLNKGTFKEQNDKPYCQSCFLKLF 1124

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PaxNP_001033913.1 LIM1_Paxillin_like 348..400 CDD:259830 38/51 (75%)
LIM2_Paxillin_like 407..458 CDD:188723 39/50 (78%)
LIM3_Paxillin_like 466..518 CDD:188724 36/51 (71%)
LIM4_Paxillin 525..576 CDD:188795 44/50 (88%)
PxnXP_038945530.1 Paxillin 121..320 CDD:397550
LIM1_Paxillin_like 892..944 CDD:259830 38/51 (75%)
LIM2_Paxillin 951..1002 CDD:188791 39/50 (78%)
LIM3_Paxillin_like 1010..1062 CDD:188724 36/51 (71%)
LIM4_Paxillin 1069..1120 CDD:188795 44/50 (88%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166343623
Domainoid 1 1.000 111 1.000 Domainoid score I6155
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 481 1.000 Inparanoid score I1405
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1593918at2759
OrthoFinder 1 1.000 - - FOG0000055
OrthoInspector 1 1.000 - - oto96865
orthoMCL 1 0.900 - - OOG6_104097
Panther 1 1.100 - - LDO PTHR24216
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X39
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.900

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