DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and lim-9

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001300395.1	Gene:	lim-9 / 3565712	WormBaseID:	WBGene00006407	Length:	793	Species:	Caenorhabditis elegans

Alignment Length:	620	Identity:	137/620 - (22%)
Similarity:	220/620 - (35%)	Gaps:	161/620 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 YGTVQPKHQALQQQQFVDNTPGYGSLRGKAQPQVYQ------------EHYSVETRSPTAGHDFN 102
            ||....|.:..::..||:    |..|.....|..::            .:.....|.|..|.  :
Worm   178 YGNENEKPENEEEGAFVE----YEKLDKTEDPAAFKVCQATTAVNRTYNNIRPSYRMPIGGG--S 236

  Fly   103 GSSTTPGYANQGSLPRQAAGASTGLSELDS------------------------LLQDLQKIDVP 143
            |||:       ||:.|:....|..|::::.                        ...|....::|
Worm   237 GSSS-------GSISREIRIESMNLTDVEDGARCRDKECHLGWKQHPWRKVCVHCKSDRSDHELP 294

  Fly   144 VNYSTPVSKYNTM-----------------------NSYATVE---ERPSVDSLLKELDNAHIYA 182
            .|.:..|  ||.:                       :.||.|.   .|..|:..:.:|.| ::..
Worm   295 PNQALNV--YNRLGIQPPAGMPQSGVAEPEVPGSVGHGYAWVPPGLSRKKVEEYMSQLPN-NVVP 356

  Fly   183 VPNGSAHK---------------SPTPGRHVTITVRETKTEKLTGPDGPVGTVEEQIVQQKD--- 229
            ..|.:..|               |....||:|     ::||:         .|.|:.|..::
Worm   357 RTNSNGEKLREKQLLLQLPRQDLSVAYCRHLT-----SQTER---------KVYEEFVNARNEIA 407

  Fly   230 ---SYTPNHAVPGQQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTV 291
               .|..::.....:.|:......|.|:..:...|.|          ..|.||...:.....|.:
Worm   408 LDIGYVSSNINKAMECHKCSGILETNEMAVIAPKLGD----------STGWHPACFTCQACEQLL 462

  Fly   292 TDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPI- 355
            .|            ||..:::..|..:....:|                   .|..|:||::.|
Worm   463 VD------------LTYCVKDNQIYCERHYAEL-------------------HKPRCSACDELIF 496

  Fly   356 VGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAI-LD-KC 418
            .|:...|:.|.||.:||.|..|.|.|..:.:..||..|||...|.::|:.:|..|...| :| |.
Worm   497 AGEYTKAMNKDWHSDHFCCWQCDQTLTGQRYIMRDEQPYCIKCYEDVFANQCDECAKPIGIDSKD 561

  Fly   419 VTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCN---RAIMENYISA 480
            ::..||.||...|.|:.|.....:..|..::.:.:|.|.|.:.||.:|:|||   ||.|:. :..
Worm   562 LSYKDKHWHEHCFLCSMCKISLVDMPFGSKNDRIFCSNCYDQAFATRCDGCNEIFRAGMKK-MEY 625

  Fly   481 LNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFH 545
            ...|||..||.|..|:......||.......:|...|..|..:.|:.|.|.||...:|...:.:|
Worm   626 KGKQWHDKCFCCAHCKLAIGTKSFIPKNDDVFCGPCYEEKFATRCSKCKKVITAGGVTYKNEPWH 690

  Fly   546 PEHFVCAFCLKQLNKGTFKEQKDKPYCHTCFDKIF 580
            .|.|.|..|...|....|..:.:||||..|:..:|
Worm   691 RECFCCTNCNSSLAGQRFTSKDEKPYCANCYGDLF 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	20/52 (38%)
		LIM2_Paxillin_like	407..458	CDD:188723	15/52 (29%)
		LIM3_Paxillin_like	466..518	CDD:188724	17/54 (31%)
		LIM4_Paxillin	525..576	CDD:188795	17/50 (34%)
lim-9	NP_001300395.1	PET_LIMPETin_LIM-9	329..412	CDD:193605	18/97 (19%)
		LIM1_LIMPETin	423..480	CDD:188798	13/78 (17%)
		LIM2_Testin_like	486..541	CDD:188727	20/54 (37%)
		LIM3_LIMPETin	544..602	CDD:188805	16/57 (28%)
		LIM4_LIMPETin	609..662	CDD:188809	17/53 (32%)
		LIM5_LIMPETin	670..721	CDD:188814	17/50 (34%)
		LIM6_LIMPETin	729..784	CDD:188816
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910