DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Limd1

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001106208.1	Gene:	Limd1 / 316101	RGDID:	1309830	Length:	663	Species:	Rattus norvegicus

Alignment Length:	648	Identity:	138/648 - (21%)
Similarity:	214/648 - (33%)	Gaps:	185/648 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DPGARQPYRTARSKGILPGYALLA-DLQNSVPGQPQQPQPQYGTVQPKHQALQQQQFVDNTPGYG 73
            |..|:.|.....   :.||.|... .:|:|.|.|.|:.:|.....:|..|            ..|
  Rat    94 DGAAKPPLAVPT---VAPGLATTTMAVQSSYPPQEQRTRPSAHGARPGSQ------------NCG 143

  Fly    74 SLRGKAQPQ-------------------VYQEHYSVET--------RSPTAGHDFNGSSTTPGYA 111
            |..|....|                   .|.:::|:.:        .||:.  ..:..|..||..
  Rat   144 SREGPVSSQRPALHGLGPCEDPSCLTHGDYYDNFSLASPQWGDKPEESPSM--SLSVGSGWPGCP 206

  Fly   112 NQGSLPRQAAGAS-------------------------------TGL-SELDSLLQDLQKIDVPV 144
            ...||..::.|.|                               ||| |...|...:|......:
  Rat   207 GNDSLSHRSCGDSHPYHPQLSMCSGRSFESGQDSGIGGHSSEKPTGLWSTASSQRVNLGFSSTGL 271

  Fly   145 NYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHK---------SPTPGRHVTI 200
            ...||.....|..|...|....|..:.|:. |::..|..| |...|         ...|..::::
  Rat   272 ENGTPAQPKGTTVSAPMVPSSTSQGACLRR-DSSLGYEAP-GRVFKPLVDTQPWLQDGPKSYLSV 334

  Fly   201 TV--------RETKTEKLTGPDGPVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATKELDDL 257
            :.        ...:|....|.|..:|.||        |.|.....|...||...::.:.....:.
  Rat   335 SAPLSSTTSKDNAQTGMTAGLDPKLGCVE--------SGTSPKPSPTSNVHPVMSAPSELSCKES 391

  Fly   258 MASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEETTIVEDSRED 322
            ..|.|    ::.:.|......|......:..||:|  ..|..|...|.|
  Rat   392 PPSWS----TDSSLGPVLPESPTPSRVRLPCQTLT--PGPELGPSTAEL---------------- 434

  Fly   323 QLDSMLGNLQANMSRQGVNTVQKGCCNACEKPI--VGQVITALGKTWHPEHFTCNHCSQELGTRN 385
            :|:::...|:..|... ......|.|..|.|.:  .||...|:|..:|...|||..||::|..:.
  Rat   435 KLEALTQRLEREMDAH-PKADYFGACVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKA 498

  Fly   386 FFERDGFPYCEPDYHNLFS------PRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEEG 444
            |:..:|..:||.|:  |:|      .||..|...|:|..:.||.|::|...|.|..|.:......
  Rat   499 FYFVNGKVFCEEDF--LYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVP 561

  Fly   445 FH-ERDGKPYCRNDYFEMFAPKCNGCNRAIMEN-------YISALNSQWHPDCFVCRDCRQPFQG 501
            |. :.:.|.||..||.::.||||..|...|:..       .:.:::..:|.:|:.|.||     |
  Rat   562 FTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDC-----G 621

  Fly   502 GSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFHP--EHFVCAFC-LKQLNKG 561
            ....|.:|        |                ||        :|  :|..|..| :|:|.||
  Rat   622 LELNDEDG--------H----------------RC--------YPLEDHLFCHSCHVKRLEKG 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	19/53 (36%)
		LIM2_Paxillin_like	407..458	CDD:188723	15/51 (29%)
		LIM3_Paxillin_like	466..518	CDD:188724	11/58 (19%)
		LIM4_Paxillin	525..576	CDD:188795	10/40 (25%)
Limd1	NP_001106208.1	Mediates nuclear export. /evidence=ECO:0000250	54..128		11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..99		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..158		12/52 (23%)
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	180..251		9/72 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253		1/22 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..297		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..416		15/92 (16%)
		Interaction with RB1. /evidence=ECO:0000250	391..429		8/43 (19%)
		Necessary for nuclear localization. /evidence=ECO:0000250	459..663		64/233 (27%)
		LIM1_Ajuba_like	459..512	CDD:188738	18/52 (35%)
		LIM2_Ajuba_like	524..576	CDD:188741	15/51 (29%)
		LIM3_Ajuba_like	584..645	CDD:188822	17/97 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910