DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Pdlim2

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001007623.1	Gene:	Pdlim2 / 290354	RGDID:	1359203	Length:	349	Species:	Rattus norvegicus

Alignment Length:	356	Identity:	67/356 - (18%)
Similarity:	109/356 - (30%)	Gaps:	102/356 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LRGKAQPQVYQEHYSVE---TRSPTAGHDFNGSSTTPGYANQGSLPRQAAGASTGLSELDSLLQD 136
            |..:||.::.|....:.   .||.||         :||..|             |...||.|...
  Rat    61 LHAEAQSKIRQSASPLRLQLDRSQTA---------SPGQIN-------------GEGSLDMLATR 103

  Fly   137 LQKIDVPVNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRHVTIT 201
            .|. .:..::::..|:.:...|.|::..||.                   |...:|.|...:.::
  Rat   104 FQG-SLRTHHNSQSSQRSACFSPASLSPRPD-------------------SPFSTPPPTSPIALS 148

  Fly   202 VRE---------------TKTEKLTGPDGPVGTVEEQIVQQKDSYTPNHAV-------PGQQVHQ 244
            ...               ..|..||.|..|..       ||....:|:.:.       ||:....
  Rat   149 GENVIGCSFQSLTHSPGLAATHHLTYPGQPTS-------QQAGHSSPSDSTVRVLLHSPGRPSSP 206

  Fly   245 AYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQT 309
            ..:|...:|..::...|.:       |..|..: |:|.||....|...:  ...:|...|.:..:
  Rat   207 RLSSLDLEEDSEVFKMLQE-------NRQGRAA-PRQSSSFRLLQEALE--AEERGGTPAFVPSS 261

  Fly   310 IEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITAL-GKTWHPEHFT 373
            :.....:..||            |..:...::|     |..|...|..|.:... |:..||..:|
  Rat   262 LSPKASLPTSR------------ALATPPKLHT-----CEKCSVNISNQAVRIQEGRYRHPGCYT 309

  Fly   374 CNHCSQELGTRNFFERDGFPYCEPDYHNLFS 404
            |..|...|..|..|......|||......:|
  Rat   310 CADCGLNLKMRGHFWVGNELYCEKHARQRYS 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	16/52 (31%)
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
Pdlim2	NP_001007623.1	PDZ_signaling	9..80	CDD:238492	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..95		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..147		8/57 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..212		11/50 (22%)
		DUF4749	<190..252	CDD:292558	12/71 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..272		2/21 (10%)
		LIM_Mystique	283..335	CDD:188833	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900