DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax and Pdlim7

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_038951356.1	Gene:	Pdlim7 / 286908	RGDID:	628769	Length:	464	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	127/488 - (26%)
Similarity:	175/488 - (35%)	Gaps:	118/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GHDFN-----------GSSTTPGYA-----------NQGSLPR-------QAAG--ASTGLSELD 131
            |.|||           |.:...|.|           |.|||..       :|.|  .|.|||...
  Rat    21 GKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQ 85

  Fly   132 SLLQDLQKIDVP------VNYSTPVSKYNTMNSYATVEERPSVDS--------------LLKELD 176
            ......||...|      ..::...|...|...:..   .|..||              ||::|
  Rat    86 PAQSKPQKALTPPADPPRYTFAPSASLNKTARPFGA---PPPTDSALSQNGCRPLTSQQLLRQL- 146

  Fly   177 NAHIYAVPNGSAHK--------SPTPG----RHVTITVRETKTEKLTGPDGPVGTVEEQIVQQK- 228
                  ||:.|..:        .|.||    |...|....|.||.:..||........|:.:.:
  Rat   147 ------VPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEFMKKSSQVPRTEA 205

  Fly   229 ---DSYTPNHAVPGQQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQT 290
               .|..|..:.||... .:.||:....:|...|.                .:....:|||.
  Rat   206 PAPASTIPQESWPGPTT-PSPTSRPPWAVDPAFAE----------------RYAPDKTSTVL--- 250

  Fly   291 VTDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPI 355
                   .:.||.|..|.....|:||:        :..|......|..|...|    |:.|.|.|
  Rat   251 -------TRHSQPATPTPLQNRTSIVQ--------AAAGGGTGGGSNNGKTPV----CHQCHKII 296

  Fly   356 VGQVITALGKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVT 420
            .|:.:.|||..:|||.|.|:.|.:.|....|||..|..:|...|...::|.||.|...|..:.:.
  Rat   297 RGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPSCYDVRYAPSCAKCKKKITGEIMH 361

  Fly   421 ALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAI--MENYISALNS 483
            ||..|||...|.||.|........|:..:|.|||..||.:||..||.||:..|  .:.::.||..
  Rat   362 ALKMTWHVPCFTCAACKTPIRNRAFYMEEGAPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGF 426

  Fly   484 QWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETH 516
            .||..||||..|:...:|.:|:..:..|.|::|
  Rat   427 SWHDTCFVCAICQINLEGKTFYSKKDKPLCKSH 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	20/51 (39%)
		LIM2_Paxillin_like	407..458	CDD:188723	18/50 (36%)
		LIM3_Paxillin_like	466..518	CDD:188724	18/53 (34%)
		LIM4_Paxillin	525..576	CDD:188795
Pdlim7	XP_038951356.1	PDZ_signaling	5..79	CDD:238492	13/57 (23%)
		PHA03247	<11..261	CDD:223021	56/276 (20%)
		DUF4749	<163..192	CDD:406377	10/28 (36%)
		LIM1_Enigma	289..340	CDD:188836	20/50 (40%)
		LIM2_Enigma	348..399	CDD:188840	18/50 (36%)
		LIM3_Enigma	407..461	CDD:188842	18/53 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810