DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and DUX5

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_036281.2	Gene:	DUX5 / 26581	HGNCID:	3083	Length:	197	Species:	Homo sapiens

Alignment Length:	158	Identity:	37/158 - (23%)
Similarity:	55/158 - (34%)	Gaps:	44/158 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PGARQPYRTARSKGILPGYALLADLQNSVPGQPQQPQPQYGTVQ-PKHQALQQQQFVDNT-PGYG 73
            |.:..|.::.:.:..||..|||..|.:::|.:.|.|..:...:. |......:..|..|. ||..
Human    10 PASLCPCQSVKFRPGLPEMALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIA 74

  Fly    74 SLRGKAQ------PQV---YQEHYSVE-------------TRSPTAGH----DFNGSSTT----- 107
            :....||      |:|   :|...|.:             .|.|..|.    ...||.|.
Human    75 TKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRA 139

  Fly   108 ------PGYANQGSLPRQAAGASTGLSE 129
                  ||.|.:..|.|:     |||.|
Human   140 FEKDRFPGIAAREELARE-----TGLPE 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
DUX5	NP_036281.2	Homeobox	54..99	CDD:306543	10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..127		3/25 (12%)
		Homeobox	124..177	CDD:306543	12/44 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910