DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax and FHL2

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001034581.1	Gene:	FHL2 / 2274	HGNCID:	3703	Length:	279	Species:	Homo sapiens

Alignment Length:	215	Identity:	66/215 - (30%)
Similarity:	100/215 - (46%)	Gaps:	4/215 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 EHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKC--VTALDKTWHTEHFF 432
            |.|.|:||::.|..:.:..|:..|||...:..||:..|..|...|...|  ::..|:.||...|.
Human     3 ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFH 67

  Fly   433 CAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIM--ENYISALNSQWHPDCFVCRDC 495
            |:||.....::.|..::.:..|.:.|...::.||..|.:.||  ...:....|.||..||:|..|
Human    68 CSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRC 132

  Fly   496 RQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFHPEHFVCAFCLKQLNK 560
            :||....||...:...:|...|..:....|..|.||||...:|...:.:|.|.|||..|.|||:.
Human   133 QQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSG 197

  Fly   561 GTFKEQKDKPYCHTCFDKIF 580
            ..|..:.|..||..||..::
Human   198 QRFTARDDFAYCLNCFCDLY 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	10/29 (34%)
		LIM2_Paxillin_like	407..458	CDD:188723	13/52 (25%)
		LIM3_Paxillin_like	466..518	CDD:188724	16/53 (30%)
		LIM4_Paxillin	525..576	CDD:188795	20/50 (40%)
FHL2	NP_001034581.1	LIM	<5..33	CDD:413332	9/27 (33%)
		LIM1_FHL2	36..97	CDD:188806	15/60 (25%)
		LIM2_FHL2	101..157	CDD:188810	17/55 (31%)
		LIM3_Fhl2	162..218	CDD:188815	22/56 (39%)
		LIM4_FHL2	221..278	CDD:188817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910