DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Tgfb1i1

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_036008777.1	Gene:	Tgfb1i1 / 21804	MGIID:	102784	Length:	496	Species:	Mus musculus

Alignment Length:	536	Identity:	214/536 - (39%)
Similarity:	289/536 - (53%)	Gaps:	96/536 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 SVETRSPTAGHDF---NGSSTTP--------GYANQGSLPRQAAGAS-----TGLSELDSLLQDL 137
            :|..|.|.:.|..   :.|.|:|        |:..:.:||:.:|.|.     ||..|......|.
Mouse    14 TVSQRVPASIHGHGPASNSLTSPPSPSSAPTGHGPRPTLPKLSASAPPWRTWTGSGESSGTTGDK 78

  Fly   138 QKIDVPVNYST-----------PVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHKS 191
            ..:     |||           ||:...:.:|.........:|.||:|| ||..:.:
Mouse    79 DHL-----YSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDRLLQEL-NATQFNI-------- 129

  Fly   192 PTPGRHVTITVRETKTEKLTG--PDGPVGTVEEQIVQQKDSYTPNHAVPGQQVH----------- 243
                           |:::..  |...:...||:..|.:|..:|......:.:|
Mouse   130 ---------------TDEIMSQFPSSKMAEGEEKEDQSEDKSSPTVLAGSEVIHGVLHSPPSPFP 179

  Fly   244 ---QAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAH 305
               :...:.||:|||.||||||||:|.|.....|....|.  :|..:....:...:.:|||
Mouse   180 APSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPA--ASPTREGCPSPPGQTSKGS---- 238

  Fly   306 LTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPE 370
                              ||:|||.||:::||:||.|..||.|.:|.|||.|||:||||:.||||
Mouse   239 ------------------LDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPE 285

  Fly   371 HFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQ 435
            ||.|:.||..||..:|||:||.|:|...|...|||||.:||..|..|.||||...||.|||.|..
Mouse   286 HFLCSGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVS 350

  Fly   436 CGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIMENYISALNSQWHPDCFVCRDCRQPFQ 500
            ||:.|||||||||:|:||||.|:.::|||:|.||...|::||||||::.|||||||||:|..||.
Mouse   351 CGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFS 415

  Fly   501 GGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFHPEHFVCAFCLKQLNKGTFKE 565
            |||||:|||.|.||.|:||:||||||.|..|:||||::|:.::|||:||.|.|||:.|.||:|:|
Mouse   416 GGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQE 480

  Fly   566 QKDKPYCHTCFDKIFG 581
            :..||||..||.|:||
Mouse   481 RASKPYCQPCFLKLFG 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	30/51 (59%)
		LIM2_Paxillin_like	407..458	CDD:188723	31/50 (62%)
		LIM3_Paxillin_like	466..518	CDD:188724	34/51 (67%)
		LIM4_Paxillin	525..576	CDD:188795	27/50 (54%)
Tgfb1i1	XP_036008777.1	Paxillin	4..>128	CDD:397550	29/119 (24%)
		LIM1_Paxillin_like	263..315	CDD:259830	30/51 (59%)
		LIM2_Paxillin_like	322..373	CDD:188723	31/50 (62%)
		LIM	381..433	CDD:413332	34/51 (67%)
		LIM4_Leupaxin	440..491	CDD:188796	27/50 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839773
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1093
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.930