DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pax and Pxn

DIOPT Version :9

Sequence 1:NP_001033913.1 Gene:Pax / 35215 FlyBaseID:FBgn0041789 Length:581 Species:Drosophila melanogaster
Sequence 2:XP_006530265.1 Gene:Pxn / 19303 MGIID:108295 Length:1088 Species:Mus musculus


Alignment Length:731 Identity:283/731 - (38%)
Similarity:361/731 - (49%) Gaps:176/731 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 MYGKIDPGAR-------QPYRTARSKGILPGYALLADLQNSVPGQPQ-----QPQPQYGT----- 52
            :.|.:.|.:|       .|.|:..|.|.|..:....:....:.||||     :|:..:|.     
Mouse   378 LMGAVGPPSRTPPCHTPYPARSIGSPGPLANHVFSEETVAPIWGQPQALTASRPESPHGVTYSFQ 442

  Fly    53 --VQPKHQALQQQQFVDNT-----------------PGYGS----------LRGKAQPQVYQEHY 88
              ::|...||.:|..:.:|                 .|.||          ||||. ||    ..
Mouse   443 EGLEPPAVALDRQDILPDTWALTKECALQERVQSEPEGLGSTCPAAGDKEPLRGKT-PQ----KG 502

  Fly    89 SVETRSPTAGHDFNGSSTT------------PGYANQGSLPRQAAGASTGLSELDSLLQDLQKID 141
            |:...:...|...|...||            |.||.....|..:...||. .::.|:::..::..
Mouse   503 SLGGPTEALGSPGNPEGTTEATLEARKEQPEPSYAMAVGTPSVSERISTS-GQIRSVIRRSRETG 566

  Fly   142 VPVNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAHKSPTPGRH-----VTIT 201
            .....|..:|....::. |::...||.:.|:.||...  ..:...:...:.||.:.     |.||
Mouse   567 HVHPMSRELSPRRRLDP-ASLSRNPSQEQLIAELQGR--LGIQLAAEEVAGTPEQDWLTEGVVIT 628

  Fly   202 VRETKTEKLTGPDG--PVGTVEEQIVQQKDSYTP------------------NHAVPGQQVHQAY 246
            |:         |.|  ..|.:.|::|...||..|                  :|..|........
Mouse   629 VQ---------PRGRQAGGQLVEKVVYPPDSPVPLRRTISVVAPSPPAPLLQDHPDPSTGSSPLP 684

  Fly   247 TSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHS------STVQH-------QTVTD----- 293
            .|..|......:|:.|.......|.|   |..|::..      ::|.|       ||..|     
Mouse   685 PSLPTPSWPGPLAAASASSSGVQTEG---GKSPEEGGRGPPGLTSVPHTVRSVGCQTNEDPLFCP 746

  Fly   294 -------------YARPN--KGSQQAHLTQTIEETTIVE---------DSRE------------- 321
                         .:||.  ..|:.|...|.:|:....|         .||:             
Mouse   747 MQAGLQAPCPARALSRPEPPPNSEDAAEMQGLEQRVDGERPWAASWPPSSRQSSPEGQDEGGFMA 811

  Fly   322 -----------------DQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHP 369
                             .|||||||:||:::::.||.||.||.|.||:|||.|||:||:||||||
Mouse   812 QGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHP 876

  Fly   370 EHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCA 434
            |||.|.||.:|:|:||||||||.||||.|||:||||||.||||.||||.|||||:|||.||||||
Mouse   877 EHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCA 941

  Fly   435 QCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIMENYISALNSQWHPDCFVCRDCRQPF 499
            |||..||.|||||:|||.|||.|||:||||||.||.|||:||||||||:.|||:|||||:|..||
Mouse   942 QCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPF 1006

  Fly   500 QGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFHPEHFVCAFCLKQLNKGTFK 564
            ..||||:|:|.||||.|||.:|||||:||.|||||||||||.|||||||||||||||||||||||
Mouse  1007 VNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFK 1071

  Fly   565 EQKDKPYCHTCFDKIF 580
            ||.|||||.:||.|:|
Mouse  1072 EQNDKPYCQSCFVKLF 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PaxNP_001033913.1 LIM1_Paxillin_like 348..400 CDD:259830 38/51 (75%)
LIM2_Paxillin_like 407..458 CDD:188723 39/50 (78%)
LIM3_Paxillin_like 466..518 CDD:188724 36/51 (71%)
LIM4_Paxillin 525..576 CDD:188795 44/50 (88%)
PxnXP_006530265.1 Paxillin 54..253 CDD:367550
LIM1_Paxillin_like 855..907 CDD:259830 38/51 (75%)
LIM2_Paxillin 914..965 CDD:188791 39/50 (78%)
LIM3_Paxillin_like 973..1025 CDD:188724 36/51 (71%)
LIM4_Paxillin 1032..1083 CDD:188795 44/50 (88%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839783
Domainoid 1 1.000 111 1.000 Domainoid score I6264
eggNOG 1 0.900 - - E1_KOG1703
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 489 1.000 Inparanoid score I1401
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1593918at2759
OrthoFinder 1 1.000 - - FOG0000055
OrthoInspector 1 1.000 - - oto93323
orthoMCL 1 0.900 - - OOG6_104097
Panther 1 1.100 - - LDO PTHR24216
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1093
SonicParanoid 1 1.000 - - X39
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.790

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