DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and SYNPO2

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_597734.2	Gene:	SYNPO2 / 171024	HGNCID:	17732	Length:	1261	Species:	Homo sapiens

Alignment Length:	356	Identity:	74/356 - (20%)
Similarity:	108/356 - (30%)	Gaps:	116/356 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KIDPGARQPYRTARSKGILP----------GYALLADLQNSVP-----GQPQQPQPQYGTVQPKH 57
            |..|.|.||.:..:.||..|          .|.|.|.|....|     |.||:...:..:.....
Human   939 KSQPSAAQPSKMGKKKGKKPLNALDVMKHQPYQLNASLFTFQPPDAKDGLPQKSSVKVNSALAMK 1003

  Fly    58 QALQ------------QQQFVDNTPGYGSLRGKAQPQVYQEHYSVETRSPTAGHDFNGSSTTPGY 110
            |||.            |...|.:.|.|.|     .|..:.|..|..:.||..    .|..|:|..
Human  1004 QALPPRPVNAASPTNVQASSVYSVPAYTS-----PPSFFAEASSPVSASPVP----VGIPTSPKQ 1059

  Fly   111 ANQGS----LPRQAAGA-STGLSELDS-LLQDLQKIDVPVNYSTPVSKYNTMNSYATVEERPSVD 169
            .:..|    .||....| .:|::..:| ....|....||...||....|....||::   :|: |
Human  1060 ESASSSYFVAPRPKFSAKKSGVTIQESGRSLSLPGRSVPPPISTSPWVYQPTYSYSS---KPT-D 1120

  Fly   170 SLLKELDNAHIYAVPNGSAHKSPTPGRHVTITVRETKTEKLTGPDGPVG---------TVEEQIV 225
            .|.|              |:|.|||..              .....|:|         .::|.||
Human  1121 GLEK--------------ANKRPTPWE--------------AAAKSPLGLVDDAFQPRNIQESIV 1157

  Fly   226 QQKDSYTPNHAVPG------------QQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSH 278
            ....|......:||            .|..:||.....::         ::.|:...|......:
Human  1158 ANVVSAARRKVLPGPPEDWNERLSYIPQTQKAYMGSCGRQ---------EYNVTANNNMSTTSQY 1213

  Fly   279 PQQ------------HSSTVQHQTVTDYARP 297
            ..|            .|:.:..:|.:||..|
Human  1214 GSQLPYAYYRQASRNDSAIMSMETRSDYCLP 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
SYNPO2	NP_597734.2	Interaction with VPS18. /evidence=ECO:0000269\|PubMed:23434281	1..180
		PDZ_signaling	7..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..369
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q91YE8	398..406
		Interaction with ACTN2. /evidence=ECO:0000269\|PubMed:20554076	481..663
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..803
		F-actin binding. /evidence=ECO:0000269\|PubMed:23225103	534..663
		Interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q91YE8	607..811
		Interaction with BAG3. /evidence=ECO:0000269\|PubMed:23434281	615..626
		PPPY motif. /evidence=ECO:0000305\|PubMed:23434281	619..622
		Interaction with ACTN2. /evidence=ECO:0000269\|PubMed:20554076	664..924
		F-actin bundling activity. /evidence=ECO:0000269\|PubMed:23225103	664..916
		F-actin binding. /evidence=ECO:0000269\|PubMed:23225103	664..803
		Actin binding. /evidence=ECO:0000250\|UniProtKB:Q91YE8	751..900
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..870
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	937..956		6/16 (38%)
		Interaction with ZYX. /evidence=ECO:0000269\|PubMed:16885336	1000..1019		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1041..1064		6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900