DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and PRICKLE2

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_011531734.1	Gene:	PRICKLE2 / 166336	HGNCID:	20340	Length:	966	Species:	Homo sapiens

Alignment Length:	367	Identity:	91/367 - (24%)
Similarity:	140/367 - (38%)	Gaps:	76/367 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 PNGSAHK-------SPTPGRHVTITVRETKTEKL------------TGPDGPVGTVEEQIVQQKD 229
            |..:.||       ...|.....:||...:.||.            |..|.....:||.
Human    71 PGFALHKWRKICLHCKCPQEEHMVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEY------ 129

  Fly   230 SYTPNHAVPG---QQVHQAYTSQATKELDDLMASLSDFKVSNGTNGIGNGSHPQQHSSTVQHQTV 291
            ::.|    ||   :||||.|            :.|.:.||.. .|..|.....:|    :.||
Human   130 AWVP----PGLKPEQVHQYY------------SCLPEEKVPY-VNSPGEKLRIKQ----LLHQ-- 171

  Fly   292 TDYARPNKGSQQAHLTQTIEETTIVEDSREDQLDSMLGNLQANMSRQGVN----TVQKGCCNACE 352
               ..|:  ..:.....:::|    |:.||.:|.|. ...:.|:.|..|.    |:....|..|.
Human   172 ---LPPH--DNEVRYCNSLDE----EEKRELKLFSS-QRKRENLGRGNVRPFPVTMTGAICEQCG 226

  Fly   353 KPIVGQVITAL------GKTWHPEHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCN 411
            ..|.|..|...      |..|||..|.|..|::.|....:|.:||..||...:.....||||.|:
Human   227 GQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACD 291

  Fly   412 GAIL-DKCVTALDKTWHTEHFFCAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNR--AI 473
            ..|. |:|..|..:.||.:||.|.:|....|.:.:..::|:|||.:.:..::|..|:.|.:  .|
Human   292 EIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGI 356

  Fly   474 MENYISALNSQWH--PDCFVCRDCRQPFQGGSFFDHEGLPYC 513
            .:..::.....||  ..||.|..|::...|..|...:|..:|
Human   357 DQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFC 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	18/57 (32%)
		LIM2_Paxillin_like	407..458	CDD:188723	18/51 (35%)
		LIM3_Paxillin_like	466..518	CDD:188724	13/52 (25%)
		LIM4_Paxillin	525..576	CDD:188795
PRICKLE2	XP_011531734.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910