DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Fhl2

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001276462.1	Gene:	Fhl2 / 14200	MGIID:	1338762	Length:	279	Species:	Mus musculus

Alignment Length:	215	Identity:	65/215 - (30%)
Similarity:	103/215 - (47%)	Gaps:	4/215 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 EHFTCNHCSQELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKC--VTALDKTWHTEHFF 432
            |.|.|:||::.|..:.:..::..|:|...:..|::..|..|...|...|  ::..|:.||...|.
Mouse     3 ERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFH 67

  Fly   433 CAQCGQQFGEEGFHERDGKPYCRNDYFEMFAPKCNGCNRAIM--ENYISALNSQWHPDCFVCRDC 495
            |::||....::.|..::.:..|.:.|...::.||..|.:.||  ...:....|.||..||.|:.|
Mouse    68 CSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRC 132

  Fly   496 RQPFQGGSFFDHEGLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFHPEHFVCAFCLKQLNK 560
            :||....||...|...:|...|..:....|..|.||||...:|...:.:|.|.|||..|.|||:.
Mouse   133 QQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFVCTACKKQLSG 197

  Fly   561 GTFKEQKDKPYCHTCFDKIF 580
            ..|..:.:.|||.|||..::
Mouse   198 QRFTARDEFPYCLTCFCDLY 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	8/29 (28%)
		LIM2_Paxillin_like	407..458	CDD:188723	13/52 (25%)
		LIM3_Paxillin_like	466..518	CDD:188724	17/53 (32%)
		LIM4_Paxillin	525..576	CDD:188795	21/50 (42%)
Fhl2	NP_001276462.1	LIM	<5..33	CDD:413332	7/27 (26%)
		LIM	36..97	CDD:413332	14/60 (23%)
		LIM	101..157	CDD:413332	18/55 (33%)
		LIM	162..218	CDD:413332	23/56 (41%)
		LIM4_FHL2	221..278	CDD:188817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910