DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Csrp3

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_476485.2	Gene:	Csrp3 / 117505	RGDID:	71092	Length:	194	Species:	Rattus norvegicus

Alignment Length:	169	Identity:	38/169 - (22%)
Similarity:	53/169 - (31%)	Gaps:	52/169 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 KCNGCNRAIME-NYISALNSQWHPDCFVCRDCRQPFQGGSFFDHEGLPYCETHYHAKRG------ 522
            ||..|::.:.. ..|......:|..||.|..||:.....:...||...||:..|..|.|
  Rat     9 KCGACDKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRKYGPKGIGF 73

  Fly   523 SLCAGCSKPITG------------------------------------RCITAMF---------K 542
            ...|||....||                                    ||..:::         |
  Rat    74 GQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGK 138

  Fly   543 KFHPEHFVCAFCLKQLNKGTFKEQKDKPYCHTCFDKIFG 581
            .:|...|.||.|.|.|......::..:.||..|:.|.||
  Rat   139 PWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFG 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724	13/52 (25%)
		LIM4_Paxillin	525..576	CDD:188795	17/95 (18%)
Csrp3	NP_476485.2	Interaction with TCAP. /evidence=ECO:0000250\|UniProtKB:P50461	1..5
		LIM1_CRP3	9..62	CDD:188865	14/52 (27%)
		Nuclear localization signal. /evidence=ECO:0000255, ECO:0000305\|PubMed:19376126	64..69		2/4 (50%)
		Interaction with CLF2. /evidence=ECO:0000250\|UniProtKB:P50461	94..105		0/10 (0%)
		LIM2_CRP3	120..173	CDD:188866	13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910