DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax and Lpxn

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_598913.1	Gene:	Lpxn / 107321	MGIID:	2147677	Length:	386	Species:	Mus musculus

Alignment Length:	462	Identity:	205/462 - (44%)
Similarity:	258/462 - (55%)	Gaps:	86/462 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 LSELDSLLQDLQK--IDVPVNYSTPVSKYNTMNSYATVEERPSVDSLLKELDNAHIYAVPNGSAH 189
            :.|||:||::|::  ......||.|||.:                     ||..        |..
Mouse     1 MEELDALLEELERCTFQDSEEYSNPVSCH---------------------LDQQ--------STE 36

  Fly   190 KSPTPGRHVTITVRETKTEKLTGPDGPVGTVEEQIVQQKDSYTPN----HAVPGQQVHQAYTSQA 250
            :|..|           :|.|.....|....::.|:|...:...||    ...|.:.|....|| |
Mouse    37 ESKIP-----------QTPKTLSSQGNTSPLKVQLVYATNIQEPNVYSEVQEPKESVLPPKTS-A 89

  Fly   251 TKELDDLMASLSDF--KVSNGTNGIGNGSHPQQHSSTVQHQTVTDYARPNKGSQQAHLTQTIEET 313
            ..:||:|||.||:.  |||                      ...|.:|.....||.|
Mouse    90 AAQLDELMAHLSEMQAKVS----------------------VKADTSRKPLPDQQDH-------- 124

  Fly   314 TIVEDSREDQLDSMLGNLQANMSRQGVNTVQKGCCNACEKPIVGQVITALGKTWHPEHFTCNHCS 378
                   :..||||||:|:..:...|:.||.||.|.:|:|||.|:||.|||::||||||.|.||.
Mouse   125 -------KASLDSMLGDLEQELQDLGIATVPKGYCASCQKPIAGKVIHALGQSWHPEHFVCTHCK 182

  Fly   379 QELGTRNFFERDGFPYCEPDYHNLFSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFGEE 443
            :|||:..||||.|..||..|||.|||||||||...|.||.:||::||||.|||||:.||:.||.|
Mouse   183 EELGSSPFFERSGLAYCSKDYHRLFSPRCAYCAAPITDKVLTAMNKTWHPEHFFCSHCGEVFGAE 247

  Fly   444 GFHERDGKPYCRNDYFEMFAPKCNGCNRAIMENYISALNSQWHPDCFVCRDCRQPFQGGSFFDHE 508
            ||||:|.|||||.|:..||:|||.||||.::|||:||:|:.|||:||||.||...|..||||:.:
Mouse   248 GFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMNTVWHPECFVCGDCFSSFSSGSFFELD 312

  Fly   509 GLPYCETHYHAKRGSLCAGCSKPITGRCITAMFKKFHPEHFVCAFCLKQLNKGTFKEQKDKPYCH 573
            |.|:||.|||.:||:||..|.:|||||||:||..|||||||||||||.||.||.||||.:|.||.
Mouse   313 GRPFCELHYHHRRGTLCHDCGQPITGRCISAMGHKFHPEHFVCAFCLTQLPKGIFKEQNNKTYCE 377

  Fly   574 TCFDKIF 580
            .||.|:|
Mouse   378 KCFTKLF 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	31/51 (61%)
		LIM2_Paxillin_like	407..458	CDD:188723	33/50 (66%)
		LIM3_Paxillin_like	466..518	CDD:188724	30/51 (59%)
		LIM4_Paxillin	525..576	CDD:188795	35/50 (70%)
Lpxn	NP_598913.1	LD motif 1	3..15		6/11 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..52		12/72 (17%)
		LD motif 2	70..82		2/11 (18%)
		LD motif 3	92..103		7/10 (70%)
		LIM	150..204	CDD:295319	32/53 (60%)
		LIM	211..262	CDD:295319	33/50 (66%)
		LIM	270..322	CDD:295319	30/51 (59%)
		LIM4_Paxillin_like	329..380	CDD:188725	35/50 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839778
Domainoid	1	1.000	99	1.000	Domainoid score	I7075
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.810