DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax and synpo2lb

DIOPT Version :9

Sequence 1:	NP_001033913.1	Gene:	Pax / 35215	FlyBaseID:	FBgn0041789	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_001341280.3	Gene:	synpo2lb / 100001241	ZFINID:	ZDB-GENE-090828-5	Length:	1184	Species:	Danio rerio

Alignment Length:	438	Identity:	86/438 - (19%)
Similarity:	148/438 - (33%)	Gaps:	102/438 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YGKIDPGA------RQPYRTARSKGILPGYALLADLQNSVPGQ--PQQPQPQ----YGTVQPKHQ 58
            ||:.|..|      ||..:..||....|.         .:|||  ||:.:..    |.:.|....
Zfish   150 YGETDSDADVAAQERQRRQKRRSPSTSPA---------KIPGQTSPQEEETSGLSGYESTQDVMY 205

  Fly    59 ALQQQQFVDNTPGYGSLRGKA-----------QPQVYQEHYSVETRSPTAGHDFNGSSTT---PG 109
            ...|...|.:..|.|:|:.:.           |||  |..:|.:..:.:...|.:.|...   .|
Zfish   206 PQTQSWPVPDVEGMGTLQKQVMHGVARREVVFQPQ--QNEWSQQGENSSENSDQSPSGAAEVDSG 268

  Fly   110 YANQGSLP-----RQAAGASTGLSELDSLLQDLQKIDVPVNYSTPVS-----------KYNTMNS 158
            :....::|     .:.|..:..|:....::..:..:|.||:....|:           :..::..
Zfish   269 FQEPPTVPPPLVSPERAKEALMLASHRQMVPMVGPVDNPVDEELTVTYMDKARQAKLHRGESLQD 333

  Fly   159 YATVEERP---SVDSLLKELDNAH-----IYAVPNGSAHK------SPTPGRHVTITVRETKTEK 209
            ....|.|.   ::.|||.:..|.|     ::......|.|      ....|...:.|..||:.|.
Zfish   334 KQVKEARSKCRTIASLLTDAPNPHSKGVLMFKKRRQRAKKYTLTCFGSVDGESNSNTEGETEDES 398

  Fly   210 L-------TGPDG----PVGTVEEQIVQQKDSYTPNHAVPGQQVHQAYTSQATK----ELDDLMA 259
            |       ...||    |..|.:...:...|..|....||.::...:....||.    :|.:...
Zfish   399 LFPGSESELDEDGFSAAPDPTWDSGYLDVLDKRTSACIVPDREAEISPGLNATSGKGAQLFEQQR 463

  Fly   260 SLSDFKVSNGTNGIGNGSHPQ-QHSSTVQHQTVTDYARPNKGSQQAHLTQ----TIEETTIVEDS 319
            ..::..|||    :...|.|| |..||:.:..|..|...:..|....:..    .:..|::|..|
Zfish   464 KRAEEHVSN----LNTFSMPQHQGDSTLTYTPVAPYTPQSTSSLSTSMVNGEPLVVSRTSVVLSS 524

  Fly   320 -REDQLDSMLGNLQANMSRQGVNTVQK--------GCCN--ACEKPIV 356
             .:..:.|:.|.|...:.....::|..        ||.:  |...|:|
Zfish   525 PGQTPMPSLTGALPEQIDSSAASSVHNRTARPFAPGCVSNRAATAPVV 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax	NP_001033913.1	LIM1_Paxillin_like	348..400	CDD:259830	3/11 (27%)
		LIM2_Paxillin_like	407..458	CDD:188723
		LIM3_Paxillin_like	466..518	CDD:188724
		LIM4_Paxillin	525..576	CDD:188795
synpo2lb	XP_001341280.3	PDZ_signaling	5..84	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900