DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17544 and Acadvl

DIOPT Version :9

Sequence 1:	NP_001163015.1	Gene:	CG17544 / 35213	FlyBaseID:	FBgn0032775	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_037023.1	Gene:	Acadvl / 25363	RGDID:	2014	Length:	655	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	130/629 - (20%)
Similarity:	228/629 - (36%)	Gaps:	153/629 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TSFIPDLPSGGPLAVYRKRANFDWKRLRLIFEKEQGLRIKYKVWRRLENDPLFAHPSRTLPMDEQ 70
            |.|:.:|.  ||:|.:.:..|...|...|               .::|.|.|          ...
  Rat    99 TQFLKELV--GPVARFFEEVNDPAKNDSL---------------EKVEEDTL----------QGL 136

  Fly    71 KRLCAMQVNRMKHLDLVPKEIESLSFSAKTKYLMYINEALACYSPSLSVKIALGVGLFNNAIRAM 135
            |.|.|..:.       ||.|:..|..| .|:|.. :.|.:..:...:||.:.....:....|...
  Rat   137 KELGAFGLQ-------VPSELGGLGLS-NTQYAR-LAEIVGMHDLGVSVTLGAHQSIGFKGILLY 192

  Fly   136 GTE-KHQKYIEAAWNREVITCLAITELSHGSNTKSIRTTATYDPTTQEFVINTPDFEAAKCWVGN 199
            ||: :.:||:....:.:.:....:||.|.||:..|||::|...|..:.:.:|     .:|.|:.|
  Rat   193 GTKAQKEKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAVPSPCGKYYTLN-----GSKIWISN 252

  Fly   200 LGKTATVAMTFANLYTADGQNHGLHGFLIPIRDPKT------------LLSYPGVLVGDIGEKCG 252
             |..|.:...||.               .||:|..|            ..|:.||..|...:|.|
  Rat   253 -GGLADIFTVFAK---------------TPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMG 301

  Fly   253 LNGIDNGFVVFTNYRIPRDNLLNRTSDVTPEGVYESVFTEPGKVLGAALESFSAGRIGIMQESAN 317
            :...:...|.|...::|.:|:|.                |.|.....|:...:.||.|:....|.
  Rat   302 IKASNTSEVYFDGVKVPAENVLG----------------EVGDGFKVAVNILNNGRFGMAATLAG 350

  Fly   318 TLCSAAVIAVRYSAVRKQFGPERHGEEMAILEYQLHQYRIFPYLAAACVQKIATEELTSTYMEII 382
            |:.:....||.::..|.|||.:.|  ...:::.:|.:..|..|:         ||.:  .|| :.
  Rat   351 TMKAIIAKAVDHATNRTQFGDKIH--NFGVIQEKLARMAILQYV---------TESM--AYM-LS 401

  Fly   383 ARSQADSNGFDVLTQNAAEIHALISSSKPLITWAARDAIQEAREACGGHGYLQAAKLGQMRTDHD 447
            |........|.:    .|.|..:..|.   ..|...|   |..:..||.|:::...:.::..|..
  Rat   402 ANMDQGFKDFQI----EAAISKIFGSE---AAWKVTD---ECIQIMGGMGFMKEPGVERVLRDIR 456

  Fly   448 PLCTYEGDNNVL------------GQQASNWLLRQWSAKELETPIGSV--------KFLERRSEL 492
            ....:||.|::|            |::.:.      ....|:.|:|:|        |.|.||:.:
  Rat   457 IFRIFEGTNDILRLFVALQGCMDKGKELTG------LGNALKNPLGNVGLLIGEASKQLRRRTGI 515

  Fly   493 -LALNYASLAQKTPIASWQFSLRCYEWLLCHLMAKTTAHIEGQLAAGSSKFEARNNSQVAGAREL 556
             ..|:.:.:.......|.:.:::..|.....:.||...|.:|.:           |.|.. .:.|
  Rat   516 GSGLSLSGIVHPELSRSGELAVQALEQFATVVEAKLMKHKKGIV-----------NEQFL-LQRL 568

  Fly   557 SLAYAEYYALTRYVDHVS-TLTVEAPYASVLRLLFDVYAMWLLE 599
            :....:.||:...:...| :|:...|.|...::|.|   .|.:|
  Rat   569 ADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCD---SWCIE 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17544	NP_001163015.1	AXO	16..670	CDD:173839	127/619 (21%)
CG17544	NP_001163015.1	PLN02443	18..687	CDD:178062	125/617 (20%)
Acadvl	NP_037023.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	41..482		101/479 (21%)
		VLCAD	72..481	CDD:173850	101/478 (21%)
		CaiA	100..473	CDD:224871	100/469 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	461..463		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	483..516		8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810