DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17544 and Acadvl

DIOPT Version :9

Sequence 1:	NP_001163015.1	Gene:	CG17544 / 35213	FlyBaseID:	FBgn0032775	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_059062.1	Gene:	Acadvl / 11370	MGIID:	895149	Length:	656	Species:	Mus musculus

Alignment Length:	634	Identity:	133/634 - (20%)
Similarity:	231/634 - (36%)	Gaps:	153/634 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSEDTSFIPDLPSGGPLAVYRKRANFDWKRLRLIFEKEQGLRIKYKVWRRLENDPLFAHPSRTL 65
            :..|...|:.:|.  ||:|.:.:..|...|...|               .::|:|.|
Mouse    95 LSEEQAQFLKELV--GPVARFFEEVNDPAKNDAL---------------EKVEDDTL-------- 134

  Fly    66 PMDEQKRLCAMQVNRMKHLDLVPKEIESLSFSAKTKYLMYINEALACYSPSLSVKIALGVGLFNN 130
              ...|.|.|..:.       ||.|:..|..| .|:|.. :.|.:..:...:||.:.....:...
Mouse   135 --QGLKELGAFGLQ-------VPSELGGLGLS-NTQYAR-LAEIVGMHDLGVSVTLGAHQSIGFK 188

  Fly   131 AIRAMGTE-KHQKYIEAAWNREVITCLAITELSHGSNTKSIRTTATYDPTTQEFVINTPDFEAAK 194
            .|...||: :.:||:....:.:.:....:||.|.||:..|||::|...|..:.:.:|     .:|
Mouse   189 GILLYGTKAQREKYLPRVASGQALAAFCLTEPSSGSDVASIRSSAIPSPCGKYYTLN-----GSK 248

  Fly   195 CWVGNLGKTATVAMTFANLYTADGQNHGLHGFLIPIRDPKT------------LLSYPGVLVGDI 247
            .|:.| |..|.:...||.               .||:|..|            ..|:.||..|..
Mouse   249 IWISN-GGLADIFTVFAK---------------TPIKDAATGAVKEKITAFVVERSFGGVTHGLP 297

  Fly   248 GEKCGLNGIDNGFVVFTNYRIPRDNLLNRTSDVTPEGVYESVFTEPGKVLGAALESFSAGRIGIM 312
            .:|.|:...:...|.|...::|.:|:|.                |.|.....|:...:.||.|:.
Mouse   298 EKKMGIKASNTSEVYFDGVKVPSENVLG----------------EVGDGFKVAVNILNNGRFGMA 346

  Fly   313 QESANTLCSAAVIAVRYSAVRKQFGPERHGEEMAILEYQLHQYRIFPYLAAACVQKIATEELTST 377
            ...|.|:.|....||.::..|.|||.:.|  ...:::.:|.:..|..|:         ||.:  .
Mouse   347 ATLAGTMKSLIAKAVDHATNRTQFGDKIH--NFGVIQEKLARMAILQYV---------TESM--A 398

  Fly   378 YMEIIARSQADSNGFDVLTQNAAEIHALISSSKPLITWAARDAIQEAREACGGHGYLQAAKLGQM 442
            ||    .|.....||     ...:|.|.|  ||...:.||.....|..:..||.|:::...:.::
Mouse   399 YM----LSANMDQGF-----KDFQIEAAI--SKIFCSEAAWKVADECIQIMGGMGFMKEPGVERV 452

  Fly   443 RTDHDPLCTYEGDNNVL------------GQQASNWLLRQWSAKELETPIGSV--------KFLE 487
            ..|......:||.|::|            |::.:.      ....|:.|.|:|        |.|.
Mouse   453 LRDIRIFRIFEGANDILRLFVALQGCMDKGKELTG------LGNALKNPFGNVGLLMGEAGKQLR 511

  Fly   488 RRSEL-LALNYASLAQKTPIASWQFSLRCYEWLLCHLMAKTTAHIEGQLAAGSSKFEARNNSQVA 551
            ||:.: ..|:.:.:.......|.:.:::..:.....:.||...|.:|.:           |.|..
Mouse   512 RRTGIGSGLSLSGIVHPELSRSGELAVQALDQFATVVEAKLVKHKKGIV-----------NEQFL 565

  Fly   552 GARELSLAYAEYYALTRYVDHVS-TLTVEAPYASVLRLLFDVYAMWLLE 599
             .:.|:....:.||:...:...| :|:...|.|...::|.|   .|.:|
Mouse   566 -LQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCD---SWCIE 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17544	NP_001163015.1	AXO	16..670	CDD:173839	130/619 (21%)
CG17544	NP_001163015.1	PLN02443	18..687	CDD:178062	128/617 (21%)
Acadvl	NP_059062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	42..483		105/484 (22%)
		VLCAD	73..482	CDD:173850	105/483 (22%)
		CaiA	95..474	CDD:224871	105/475 (22%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	462..464		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	484..517		8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810