DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fon and NUP98

DIOPT Version :9

Sequence 1:	NP_001163013.1	Gene:	fon / 35211	FlyBaseID:	FBgn0032773	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001352054.1	Gene:	NUP98 / 4928	HGNCID:	8068	Length:	1831	Species:	Homo sapiens

Alignment Length:	532	Identity:	136/532 - (25%)
Similarity:	201/532 - (37%)	Gaps:	146/532 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 STHGQAVEQARKNAGYGGGYSGSFGAGVDGASAQVDDSALGKLESSYDSVGATESAEGASAGGLG 100
            ||.||       |.|:|....|:||....|:|                          .:.|||.
Human    21 STFGQ-------NTGFGTTSGGAFGTSAFGSS--------------------------NNTGGLF 52

  Fly   101 GAVETL-GGSAGTNTI---------GAGVGSSFG-SNFASGFGGQNAASFGAQNAAGFGAQNAAS 154
            |..:|. ||..||::.         |.|.|:|.| :|...|......:.|.:||.| |.......
Human    53 GNSQTKPGGLFGTSSFSQPATSTSTGFGFGTSTGTANTLFGTASTGTSLFSSQNNA-FAQNKPTG 116

  Fly   155 FGAQNAASFGSSFSSNAAFQTSSASN--FGSTAAHQVGSNVEFADNANAGNKVDFGGVNAVDSSA 217
            ||     :||:|.||...|.|::.::  ||||:....|.:...|  |..|..:.|......|:..
Human   117 FG-----NFGTSTSSGGLFGTTNTTSNPFGSTSGSLFGPSSFTA--APTGTTIKFNPPTGTDTMV 174

  Fly   218 QLLSGVQTVQSVPTSEYYRHEKIVSTPQQVVYTIPGGSQRYVHHEERIVE----QPTQVTQTVPV 278
            :  :||.|              .:||..|.:..:.       .:|.:.:|    :..|..:..|
Human   175 K--AGVST--------------NISTKHQCITAMK-------EYESKSLEELRLEDYQANRKGP- 215

  Fly   279 QTAHYYQRKV---TTT---ASAPQLVQPVASSRLT--YGS---NAASTFGSNAASNFGSNAATNF 332
                  |.:|   |||   .|:|      |:|..|  :.|   |:...:|.|..: ||: :.|.|
Human   216 ------QNQVGAGTTTGLFGSSP------ATSSATGLFSSSTTNSGFAYGQNKTA-FGT-STTGF 266

  Fly   333 GSNAATNFG-SNAAFNSQFGSSYGQ---------NFQQNSQLSQ-------LLSQTQQAARQQAA 380
            |:|....|| .|....|.|...:||         :|...|.:.|       |...||  |.|...
Human   267 GTNPGGLFGQQNQQTTSLFSKPFGQATTTQNTGFSFGNTSTIGQPSTNTMGLFGVTQ--ASQPGG 329

  Fly   381 LQAASANQVQAGSGYAAGSQ--GGFNSGYNSAFNSGSQFGFNS----ASSLNSASSLNSASTG-- 437
            |...:.| ...|:.:..|:.  |..|:|:.:.  ..:.||.|.    .||..||.|..:.|.|
Human   330 LFGTATN-TSTGTAFGTGTGLFGQTNTGFGAV--GSTLFGNNKLTTFGSSTTSAPSFGTTSGGLF 391

  Fly   438 NSAALLSGSLLGGSQ---GSLLSGQVGGQQSLLSGSLLSGQQNLGLGLNAAQTGQVVGASSVGA- 498
            ......||:.:.||:   |:|.:|...|    ...:|.:||.:| .|.|..:.|..:|..:.||
Human   392 GFGTNTSGNSIFGSKPAPGTLGTGLGAG----FGTALGAGQASL-FGNNQPKIGGPLGTGAFGAP 451

  Fly   499 GLSAGAGNLGSG 510
            |.:.....||.|
Human   452 GFNTTTATLGFG 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fon	NP_001163013.1	None
NUP98	NP_001352054.1	Nucleoporin_FG	40..149	CDD:316182	36/140 (26%)
		Nucleoporin_FG	239..332	CDD:316182	26/96 (27%)
		Herpes_BLLF1	<243..666	CDD:330317	64/233 (27%)
		Nucleoporin_FG	363..463	CDD:316182	31/104 (30%)
		Nucleoporin2	723..862	CDD:309287
		Nup96	1348..1637	CDD:314912
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900