Protein Alignment dnt and Epha5

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_063129722.1
• Gene: Epha5 / 79208
• RGDID: 620831
• Length: 1040
• Species: Rattus norvegicus
• Alignment Length: 594
• Identity: 141/594 - (23%)
• Similarity: 230/594 - (38%)
• Gaps: 146/594 - (24%)

  Fly    41 SEVAAHLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPVP-ANVK-------DISFTWQ 97
            :::.||.|.   ..|:..:.|||......|:....|...|...|.| .|||       .||.:||
  Rat   431 ADLLAHTNY---TFEIEAVNGVSDLSPGTRQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQ 492

  Fly    98 S---LAGRGLPYSINVVSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLE 159
            .   ..|..|.|.|.....|||        .|:     |.|::....:...|||.|      |:.
  Rat   493 EPDRPNGIILEYEIKYFEKDQE--------TSY-----TIIKSKETTITAEGLKPA------SVY 538

  Fly   160 VVLNRSLNNVTHLVFRRK--------KICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVGV 216
            |...|:.....:.||.|:        .:...||.::                :|       ::.|
  Rat   539 VFQIRARTAAGYGVFSRRFEFETTPVSVAASNDQSQ----------------IP-------IIAV 580

  Fly   217 SVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAP 281
            ||.:|.:.|.:||.:.:.|:.                          |:...|.|:    |:.|.
  Rat   581 SVTVGVILLAVMIGFLLSGSC--------------------------CECGCGRAS----SLCAV 615

  Fly   282 IHGSSLPRKVPVSVEQQHPEE------------------------------LHRRISELTVERCR 316
            .| .||..:...|..:|.|||                              :|....|  :|...
  Rat   616 AH-PSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPTQAVHEFAKE--IEASC 677

  Fly   317 VRLSSLLQEGTFGRVYRGTY----NDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSV 377
            :.:..::..|.||.|..|..    .....|.:||:....::.|....|.|..::....||.|:.:
  Rat   678 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLSEASIMGQFDHPNIIHL 742

  Fly   378 LGVSIEDHTTPFVLYPALNNTRNLKQFLLDPACART---VTTIQIVMMASQLSMALDHLHSHGVV 439
            .||..:..       |.:..|..::...||....:.   .|.||:|.|...::..:.:|...|.|
  Rat   743 EGVVTKSK-------PVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDMGYV 800

  Fly   440 HKDIATRNCVIDDQLRVKLSDSSLSR---DLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASD 501
            |:|:|.||.:|:..|..|:||..|||   |...:.|...|.  ..|::|.:.||:..::|:.|||
  Rat   801 HRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG--KIPIRWTAPEAIAFRKFTSASD 863

  Fly   502 SWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTF 566
            .|::|::|||:.:..::||.|:...::...:::||||..|.:||..|:.:|..||......||.|
  Rat   864 VWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKDRNSRPKF 928

  Fly   567 AQLQSCLSE 575
            ..:.:.|.:
  Rat   929 DDIVNMLDK 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	38/154 (25%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	76/276 (28%)
Epha5	XP_063129722.1	None