Protein Alignment dnt and ZAP70

DIOPT Version :10

• Sequence 1: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: XP_054188971.1
• Gene: ZAP70 / 7535
• HGNCID: 12858
• Length: 707
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 150/704 - (21%)
• Similarity: 273/704 - (38%)
• Gaps: 177/704 - (25%)

  Fly     7 CGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGS------------------------------ 41
            |..||.||     .|.:.|....|..||....:||
Human    29 CRSSADTR-----PSGQAWPTVGLRAAAGAFRTGSPLALGPETPQVACLPGHPPVRPQVSGGPGA 88

  Fly    42 --EVAAHLNVFLNPV------EVMRLLGVSAEVYYVRE--GHINNYALNFIVPV-----PANVKD 91
              :.||||..|...:      |.::|.|::..::.:|:  ..:..|.|:.:..|     |.. :.
Human    89 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIE-RQ 152

  Fly    92 ISFTWQSLAGR-----------------GLPYSINVVSSDQEVL-PRPAI--------------- 123
            ::.|:....|:                 |||.::....:....| |:|.:
Human   153 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQ 217

  Fly   124 ------------NVSHSGEIPTTIQT-------W---SIALK------CSG--------LKAAEV 152
                        .:|.:.::...|.|       |   |:..:      .||        |:..:.
Human   218 TWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE 282

  Fly   153 DVTVSLEVVLNRSLNNVTHLVFRRK--KICLMNDSAEDLSEDVDDPQLLETVMLPPTGLITLVVG 215
            ..|.:|.::..:::.:  :|:.:.|  |.|:...:..|...     ||:|.:.|...|||
Human   283 QGTYALSLIYGKTVYH--YLISQDKAGKYCIPEGTKFDTLW-----QLVEYLKLKADGLI----- 335

  Fly   216 VSVAMGSVCLLLMIAYCVKGAA-NKRQHHQHGGQPMRTSSFQRLNTHPPCQ-SSMGSAAYMTPSI 278
                           ||:|.|. |....:..|.......:.....|||..: .::.|..| ||.
Human   336 ---------------YCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGY-TPE- 383

  Fly   279 IAPIHGSSLPRKVPVSVE-----QQHPEELHRRISELTVERCRVRLSSL-LQEGTFGRVYRGTYN 337
            .|.|.....||.:|:...     ...||||  :..:|.::|..:.::.: |..|.||.|.:|.|.
Human   384 PARITSPDKPRPMPMDTSVYESPYSDPEEL--KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR 446

  Fly   338 DTQ---DVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTR 399
            ..:   ||.:|.:.|...:.....:::|..:::...:|.|:.::||.   .....:|...:....
Human   447 MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC---QAEALMLVMEMAGGG 508

  Fly   400 NLKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLS 464
            .|.:||:..  ...:....:..:..|:||.:.:|.....||:|:|.||.::.::...|:||..||
Human   509 PLHKFLVGK--REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 571

  Fly   465 RDLFPSD-YNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEM 528
            :.|...| |.....:...|:||.:.|.:..::||..||.|::||.|||..:..::||.::...|:
Human   572 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 636

  Fly   529 EHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTF----AQLQSCLSEFYS 578
            ..:::.|.|:..|..||.||:.:|:.||.....:||.|    .::::|   :||
Human   637 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC---YYS 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_477341.2	WIF	46..182	CDD:128745	33/219 (15%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	73/278 (26%)
ZAP70	XP_054188971.1	SH2_N-SH2_Zap70_Syk_like	96..199	CDD:198191	16/103 (16%)
		SH2_C-SH2_Zap70	240..343	CDD:198265	25/129 (19%)
		PTKc_Zap-70	421..689	CDD:270686	72/275 (26%)