Protein Alignment dnt and RYK

DIOPT Version :9

• Sequence 1: NP_001260567.1
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001005861.1
• Gene: RYK / 6259
• HGNCID: 10481
• Length: 610
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 231/613 - (37%)
• Similarity: 336/613 - (54%)
• Gaps: 85/613 - (13%)

  Fly    26 VLSLLALAAL---------------QLHSGSEVAAHLNVFLNPVEVMRLLGVSAEVYYVREGHIN 75
            :|.||||..|               :|.|.| ....::::|:..||.||:|:.||:||||...|:
Human    29 LLLLLALLPLLPAPGAAAAPAPRPPELQSAS-AGPSVSLYLSEDEVRRLIGLDAELYYVRNDLIS 92

  Fly    76 NYALNFIVPVPANVKDISFTWQSLAGRGLPYSI-----NVVSSDQEVLPRPAINVSHSGEIPTTI 135
            :|||:|.:.||:....:.|||.  |...:.|.:     ||::.|.     |.:|:|..||:|.|:
Human    93 HYALSFSLLVPSETNFLHFTWH--AKSKVEYKLGFQVDNVLAMDM-----PQVNISVQGEVPRTL 150

  Fly   136 QTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICL-----MNDSAED--LSEDV 193
            ..:.:.|.|:|...:||.:.:.|.:.:|.| .|.|.|.|:|:|:|.     :..||.|  .|..:
Human   151 SVFRVELSCTGKVDSEVMILMQLNLTVNSS-KNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTI 214

  Fly   194 DDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMR------- 251
            .||     |...|| ..|.|..:||  |..|.::.:...:....     |.|..:.:.
Human   215 YDP-----VHAAPT-TSTRVFYISV--GVCCAVIFLVAIILAVL-----HLHSMKRIELDDSISA 266

  Fly   252 TSSFQRLNTHPPCQSSMGSAAYM---TPSIIAPIHGS-SLPRKVPVSVEQQHPE-----ELHRRI 307
            :||.|.|:     |.|..:..|:   ||:...||..| ..|   .:.:|:....     |...::
Human   267 SSSSQGLS-----QPSTQTTQYLRADTPNNATPITSSLGYP---TLRIEKNDLRSVTLLEAKGKV 323

  Fly   308 SELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQD------VLVKTVAQHASQMQVLLLLQEGMLL 366
            .::.:.|.|:.|..:||||||||::.|...|.:|      ..||||...||::||.::|.|...|
Human   324 KDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKL 388

  Fly   367 YGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQF-----LLDPACARTVTTIQIVMMASQL 426
            .|..|..:|.:..|.||:...|.|:.|.: |..|||.|     |::....:.::...:|.||.|:
Human   389 RGLHHRNLLPITHVCIEEGEKPMVILPYM-NWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQI 452

  Fly   427 SMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEAL 491
            :..:.:|....|:|||:|.|||||||.|:||::|::|||||||.||:||||:|||||:||:||:|
Human   453 ACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESL 517

  Fly   492 QHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCW 556
            .:.:||.|||.|||||.:|||.|..:.||.::|||||..|||||||:|||.|||||||.:||.||
Human   518 VNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCW 582

  Fly   557 ALLPAERPTFAQLQSCLSEFYSQITRYV 584
            ||.|.|||.|.||..||:||::.:..||
Human   583 ALDPEERPKFQQLVQCLTEFHAALGAYV 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnt	NP_001260567.1	WIF	46..182	CDD:128745	49/145 (34%)
		PKc_like	310..580	CDD:304357	139/280 (50%)
		Pkinase_Tyr	317..573	CDD:285015	133/266 (50%)
RYK	NP_001005861.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		WIF	63..196	CDD:128745	49/140 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..290		8/28 (29%)
		PTK_Ryk	326..606	CDD:270639	139/280 (50%)
		Pkinase_Tyr	333..599	CDD:285015	133/266 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1843
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2192
Isobase	1	0.950	-	0	Normalized mean entropy	S3376
OMA	1	1.010	-	-		QHG45854
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm41336
orthoMCL	1	0.900	-	-		OOG6_106190
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.830